VPS41 inhibitor DMBP

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Chemical Structure : VPS41 inhibitor DMBP

Catalog No.: PC-49692Not For Human Use, Lab Use Only.

DMBP is a natural small molecule with preferable anticancer activity, inhibits vacuolar protein sorting-associated protein 41 homolog (VPS41) function, a subunit of the HOPS complex.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

DMBP is a natural small molecule with preferable anticancer activity, inhibits vacuolar protein sorting-associated protein 41 homolog (VPS41) function, a subunit of the HOPS complex.
DMBP induced methuosis and inhibited autophagic flux in cancer cells by inhibiting the function of VPS41, leading to the restrained fusion of late endosomes and autophagosomes with lysosomes.
DMBP effectively inhibited metastasis in a mouse metastatic melanoma model.

Physicochemical Properties

M.Wt	340.42
Formula	C21H24O4
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	methyl 2,4-dihydroxy-3-(3-methyl-2-butenyl)-6-phenethylbenzoate

References

1. Liu Y, et al. Cell Chem Biol. 2023 Jan 24:S2451-9456(23)00023-5.

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