| Cat. No. |
Product Name |
Information |
| PC-42227 |
ML390
DHODH inhibitor
|
ML390 is a potent DHODH inhibitor that causes myeloid differentiation in murine (ER-HoxA9) and human (U937 and THP1) AML models (ED50=2 uM). |
| PC-42382 |
NIH-12848
PI5P4Kγ inhibitor
|
NIH-12848 is a potent and selective PI5P4Kγ inhibitor with IC50 of 1 uM, shows no significant inhibitory activity for PI5P4Kα and PI5P4Kβ (>100 uM). |
| PC-45393 |
Acebilustat
LTA4H inhibitor
|
Acebilustat (CTX-4430, EP-501) is a potent and selective leukotriene A4 hydrolase (LTA4H) inhibitor with IC50 of 64 nM for inhibition of LTB4 production in human whole blood. |
| PC-45593 |
Adjudin
|
Adjudin (AF-2364) is a potent analog of lonidamine known to disrupt germ cell adhesion, a potential candidate for male contraceptive development. |
| PC-45492 |
Ro 48-8071
|
Ro 48-8071 is a potent 2,3-oxidosqualene cyclase (OSC) inhibitor with IC50 of 6.5 nM. |
| PC-45095 |
ISA-2011B
|
ISA-2011B (ISA2011B, ISA 2011B) is a poent, selective inhibitor of Phosphatidylinositol-4-phosphate 5-kinase-α (PIP5Kα). |
| PC-45522 |
GBT-440
|
GBT-440 (Voxelotor) is a new potent allosteric effector of sickle cell hemoglobin. |
| PC-42293 |
EC330
|
EC330 (EC-330, EC 330) is a first-in-class LIF (leukemia inhibitory factor) inhibitor. |
| PC-45623 |
GW-4869
|
GW-4869 (GW4869, GW 4869) is a cell-permeable, potent, specific, non-competitive inhibitor of neutral sphingomyelinase (nSMase) with IC50 of 1 uM. |
| PC-42082 |
TPEN
|
TPEN (LIN28 inhibitor TPEN) is a potent, cell-permeable inhibitor of LIN28 that abolishes LIN28-mediated oligouridylation with IC50 of 2.5 uM. |
| PC-42281 |
GGTI298
GGTase I inhibitor
|
GGTI298 (GGTI-298) is a CAAZ peptidomimetic geranylgeranyltransferase I (GGTase I) inhibitor that inhibits the processing of geranylgeranylated Rap1A with little effect on processing of farnesylated Ha-Ras (IC50s are 3 and >10 uM respectively). |
| PC-22340 |
QDPR inhibitor 9b
QDPR inhibitor
|
QDPR inhibitor 9b is a small molecule inhibitor of quinonoid dihydropteridine reductase (QDPR) with IC50 of 0.72 uM. |
