Catalog No.: PC-72215Not For Human Use, Lab Use Only.
BJP-06-005-3 is a potent, selective, covalent, cell-permeable peptide Pin1 inhibitor (Ki=48 nM) that covalently target Cys113, a highly conserved cysteine located in the Pin1 active site.
BJP-06-005-3 is a potent, selective, covalent, cell-permeable peptide Pin1 inhibitor (Ki=48 nM) that covalently target Cys113, a highly conserved cysteine located in the Pin1 active site.
BJP-06–005-3 potently inhibited Pin1 catalytic activity with an apparent Ki of 48 nM in PPIase assays.
BJP-06-005-3 reduced cell viability cross a panel of cancer cell lines in a dose- and time-dependent manner.
BJP-06-005-3 increased phospho-CDK1 Tyr15 in Pin1-WT PDAC cell, but not in Pin1 KO cells, affected expression of downstream Pin1 substrates, increased c-Myc protein levels, cooperated with KRASG12V degradation.
