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Chemical Structure : OXS007417
Catalog No.: PC-72175Not For Human Use, Lab Use Only.
OXS007417 (OXS 007417) is a small moelcule that induces differentiation of AML cells in vitro (CD11b increasein HL-60 cell EC50=48 nM) and shows antitumor effects in vivo.
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OXS007417 (OXS 007417) is a small moelcule that induces differentiation of AML cells in vitro (CD11b increasein HL-60 cell EC50=48 nM) and shows antitumor effects in vivo.
OXS007417 displays favorable pharmacokinetic properties and is well-tolerated at a therapeutic dose.
OXS007417 showed activity across multiple AML cell lines and displayed a mechanistic profile consistent with differentiation, caused a clear decrease in cell numbers in the panel of AML cell lines.
OXS007417 also caused morphological changes consistent with differentiation, such as a lighter cytoplasm, a higher cytoplasm-to-nucleus ratio, an increase in granulation, and a change in the cell shape and size.
At 10 mg/kg twice daily dosing, OXS007417 significantly delayed the growth of HL-60 tumors, with a T/C of 57%.
| M.Wt | 369.347 | |
| Formula | C20H14F3N3O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Laia Josa-Culleré, et al. J Med Chem. 2021 Nov 11;64(21):15608-15628.
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