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Chemical Structure : WO-459
Catalog No.: PC-72130Not For Human Use, Lab Use Only.
WO-459 (WO459) is the first potent and orally available agonist of GPR52 with pEC50 of 7.53.
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WO-459 (WO459) is the first potent and orally available agonist of GPR52 with pEC50 of 7.53.
WO-459 induced dose-dependent elevation of intracellular cAMP in HEK293/GPR52 cells with EC50 value of 6.0 nM.
WO-459 significantly suppressed methamphetamine-induced hyperactivity in mice after oral administration of 3 mg/kg without disturbance of motor function.
| M.Wt | 459.487 | |
| Formula | C23H20F3N3O2S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Song H, et al. Brain. 2018 Jun 1;141(6):1782-1798.
2. Masaki Setoh, et al. J Med Chem. 2014 Jun 26;57(12):5226-37.
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