Welcome to ProbeChem!Global Supplier of Chemical Probes, Inhibitors & Agonists.
EN | CN

You are here:Home-Chemical Inhibitors & Agonists-Others-Other Targets-WO-459
WO-459

Chemical Structure : WO-459

CAS No.: 1313195-84-4

WO-459 (WO459)

Catalog No.: PC-72130Not For Human Use, Lab Use Only.

WO-459 (WO459) is the first potent and orally available agonist of GPR52 with pEC50 of 7.53.

Packing Price Stock Quantity
50 mg Get quote
100 mg Get quote
250 mg Get quote

Bulk size, bulk discount!

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    WO-459 (WO459) is the first potent and orally available agonist of GPR52 with pEC50 of 7.53.
    WO-459 induced dose-dependent elevation of intracellular cAMP in HEK293/GPR52 cells with EC50 value of 6.0 nM.
    WO-459 significantly suppressed methamphetamine-induced hyperactivity in mice after oral administration of 3 mg/kg without disturbance of motor function.

    Physicochemical Properties

    M.Wt 459.487
    Formula C23H20F3N3O2S
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20°C 12 Months; 4°C 6 Months
    In Solvent
    -80°C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO

    Chemical Name/SMILES

    N-(2-Hydroxyethyl)-3-methyl-1-[2-[3-(trifluoromethyl)benzyl]benzothiophen-7-yl]-1H-pyrazole-4-carboxamide

    References

    1. Song H, et al. Brain. 2018 Jun 1;141(6):1782-1798.

    2. Masaki Setoh, et al. J Med Chem. 2014 Jun 26;57(12):5226-37.

    Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright

    Contact Us sales@probechem.com

    Bulk Inquiry

    * Indicates a Required FieldYour information is safe with us.

    • *Product name:
    • *Applicant name:
    • *Email address:
    • *Organization name:
    • *Requested quantity:
    • *Country:
    • *Additional Information:

    Get Quote

    * Indicates a Required FieldYour information is safe with us.

    • *Product name:
    • *Applicant name:
    • *Email address:
    • *Organization name:
    • *Requested quantity:
    • *Country:
    • Additional Information: