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WO-459

Chemical Structure : WO-459

CAS No.: 1313195-84-4

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WO-459 (WO459)

Catalog No.: PC-72130Not For Human Use, Lab Use Only.

WO-459 (WO459) is the first potent and orally available agonist of GPR52 with pEC50 of 7.53.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    WO-459 (WO459) is the first potent and orally available agonist of GPR52 with pEC50 of 7.53.
    WO-459 induced dose-dependent elevation of intracellular cAMP in HEK293/GPR52 cells with EC50 value of 6.0 nM.
    WO-459 significantly suppressed methamphetamine-induced hyperactivity in mice after oral administration of 3 mg/kg without disturbance of motor function.

    Physicochemical Properties

    M.Wt 459.487
    Formula C23H20F3N3O2S
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20°C 12 Months; 4°C 6 Months
    In Solvent
    -80°C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    N-(2-Hydroxyethyl)-3-methyl-1-[2-[3-(trifluoromethyl)benzyl]benzothiophen-7-yl]-1H-pyrazole-4-carboxamide

    References

    1. Song H, et al. Brain. 2018 Jun 1;141(6):1782-1798.

    2. Masaki Setoh, et al. J Med Chem. 2014 Jun 26;57(12):5226-37.

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