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Chemical Structure : I194496
Catalog No.: PC-72156Not For Human Use, Lab Use Only.
I194496 (I 194496) is a novel potent, selective inhibitor of cystathionine γ-lyase (CSE) inhibitor with IC50 of 0.79 uM.
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I194496 (I 194496) is a novel potent, selective inhibitor of cystathionine γ-lyase (CSE) inhibitor with IC50 of 0.79 uM.
I194496 suppressed CSE/H2S system of TNBC cells, significantly inhibited production of H2S in MDA-MB-231 and MDA-MB-468 cells, significantly decreased the protein and mRNA levels of CSE in MDA-MB-231 and MDA-MB-468 cells, but did not affect the expression of CBS protein.
I194496 inhibits the growth, proliferation, migration and invasion of TNBC cells, blocks the PI3K/Akt and Ras/Raf/ERK signaling pathways.
I194496 inhibits the Anxa2/STAT3 and VEGF/FAK/Paxillin signaling pathways in human TNBC cells.
I194496 inhibits human TNBC xenograft tumors in nude mice.
| M.Wt | 579.579 | |
| Formula | C28H23F2N5O5S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO (5.8 mg/mL) |
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1. Ya Liu, et al. Sci Rep. 2021 Apr 26;11(1):8963.
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