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Chemical Structure : PW0787
CAS No.: 2624131-45-7
Catalog No.: PC-72127Not For Human Use, Lab Use Only.
PW0787 (PW 0787) is a potent, selective, brain-penetrant GPR52 agonist with EC50 of 135 nM in cAMP assays in HEK293 cells.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $128 | In stock | |
| 10 mg | $198 | In stock | |
| 25 mg | $358 | In stock | |
| 50 mg | $558 | In stock | |
| 100 mg | Get quote |
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PW0787 (PW 0787) is a potent, selective, brain-penetrant GPR52 agonist with EC50 of 135 nM in cAMP assays in HEK293 cells.
PW0787displays no significant binding affinity (IC50>10 uM) against other GPCRs, a broad-panel counter screening (NIMH-PDSP), as well as hERG potassium channel.
PW0787 exhibits a good concentration in the brain at 0.25 h with the value of 1807 ng/g and also exhibits an acceptable brain permeability with a brain/plasma ratio of 0.28.
PW0787 is an orally bioavailable and brain-penetrant GPR52 agonist with antipsychotic-like activity, which dose-dependently inhibits amphetamine-evoked hyperactivity in mice.
| M.Wt | 460.433 | |
| Formula | C23H20F4N4O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
1-(6-(3-Fluoro-5-(trifluoromethyl)benzyl)pyrimidin-4-yl)-N-(2-hydroxyethyl)indoline-4-carboxamide |
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1. Pingyuan Wang, et al. J Med Chem. 2020 Nov 25;63(22):13951-13972.
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