| Cat. No. |
Product Name |
Information |
| PC-24791 |
TREM2 activator 4a
TREM2 agonist
|
TREM2 activator 4a is a specific small molecule activator of triggering receptor expressed on myeloid cells 2 (TREM2) with KD of 12.7 uM, 1.5-fold selectivity over TREM1, induces SYK phosphorylation and significantly enhances microglial phagocytic activity. |
| PC-24790 |
TREM2 activator 4i
TREM2 agonist
|
TREM2 activator 4i is a specific small molecule activator of triggering receptor expressed on myeloid cells 2 (TREM2) with KD of 19.0 uM in MST assays, 2-fold selectivity over TREM1, induces SYK phosphorylation and significantly enhances microglial phagocytic activity. |
| PC-24789 |
Mitochonic acid 5
ATP synthesis modulator
|
Mitochonic acid 5 (MA-5) is a synthesized indole derivative targeting the mitochondrial protein mitofilin, modulates mitochondrial ATP synthesis independently of oxidative phosphorylation and the electron transport chain. |
| PC-24788 |
SANA
Thermogenesis inducer
|
SANA is a nitroalkene derivative of salicylate, and a first-in-class activator of creatine-dependent energy expenditure and thermogenesis, induces creatine-dependent thermogenesis and promotes weight loss. |
| PC-24771 |
Kaempferol
MARK4 inhibitor
|
Kaempferol is a natural MARK4 inhibitor with IC50 of 11.54 uM, also inhibits estrogen receptor α expression in breast cancer cells and induces apoptosis in glioblastoma cells and lung cancer cells by activation of MEK-MAPK. |
| PC-24758 |
CD39 inhibitor Compound 338
CD39 inhibitor
|
CD39 inhibitor compound 338 is a potent, selective nucleotidase NTPDase1 (CD39) inhibitor with IC50 of 68.7 nM, weakly inhibits NTPDase 2 and NTPDase 3, with IC50 values of 975.9 nM and 715.9 nM, respectively. |
| PC-24752 |
LOXL2-IN-1 tosylate
LOXL2 inhibitor
|
LOXL2-IN-1 tosylate is a selective and orally active lysyl oxidase-like 2 (LOXL2) inhibitor with IC50 of <300 nM, compound 22 extracted from patent WO2017136870A1. |
| PC-24751 |
LOXL2-IN-1
LOXL2 inhibitor
|
LOXL2-IN-1 is a selective and orally active lysyl oxidase-like 2 (LOXL2) inhibitor with IC50 of <300 nM, compound 22 extracted from patent WO2017136870A1. |
| PC-24749 |
PXS-4787 hydrochloride
pan-LOX inhibitor
|
PXS-4748 hydrochloride (PXS4748) is a potent, selective and irreversible pan-lysyl oxidase (pan-LOX) inhibitor with IC50 of 2.0 uM and 3.2/0.6/1.4/0.2 uM for bovine (aorta) LOX and rh LOXL1/2/3/4, respectively. |
| PC-24748 |
PXS-6302 hydrochloride
pan-LOX inhibitor
|
PXS-6302 hydrochloride (PXS6302) is a potent, irreversible pan-lysyl oxidase (pan-LOX) inhibitor with IC50 of 3.7 uM and 3.4/0.4/1.5/0.3 uM for bovine (aorta) LOX and rh LOXL1/2/3/4, respectively. |
| PC-24743 |
Kifunensine
alpha-mannosidase I inhibitor
|
Kifunensine (FR-900494) is a potent inhibitor of glycoprotein processing mannosidase I (alpha-mannosidase I) with IC50 of 20-50 nM, inactive toward the plant mannosidase II, kifunensine also inhibits the Golgi mannosidase I in rat liver microsomes. |
| PC-24721 |
Cavolin-1 ligand WL47
Caveolin-1 inhibitor
|
Cavolin-1 ligand WL47 is a peptide, high-affinity, selective disrupter / inhibitor of caveolin-1 (CAV) oligomerization with ITC KD of 23 nM, 7500-fold improved affinity compared to its T20 parent ligand. |
