| Cat. No. |
Product Name |
Information |
| PC-25425 |
ARN14988
Acid ceramidase inhibitor
|
ARN14988 is a potent, selective inhibitor of acid ceramidase (ACDase, ASAH1) with IC50 of 12.8 nM. |
| PC-25424 |
Pepstatin A
Aspartic protease inhibitor
|
Pepstatin A (Pepstatin) is a potent, specific, orally active aspartic protease inhibitor with IC50 of 4.5 nM, 6.2 nM, 150 nM, 290 nM, 520 nM and 260 nM for hemoglobin-pepsin, hemoglobin-proctase, casein-pepsin, casein-proctase, casein-acid protease and hemoglobin-acid protease, respectively. |
| PC-25387 |
5-O-Methylvisammioside
HMGB1 inhibitor, CNT2 inhibitor
|
5-O-Methylvisammioside (5OMV) is a flavonol compound derived from the traditional Chinese medicine plant Saposhnikovia divaricat, inhibits vasospasm induced by High Mobility Group Box 1 (HMGB1) protein, also inhibits intestinal concentrative nucleoside transporter 2 (CNT2) with IC50 of 11.22 uM, inhibits intestinal purine nucleoside absorption. |
| PC-25386 |
Ceranib-2
Ceramidase inhibitor
|
Ceranib-2 (Ceranib 2) is a small molecule ceramidase inhibitor with IC50 of 28 uM in cell-based assays, exhibits antiproliferative effect in SKOV3 cells with IC50 of 0.71 uM, induces the accumulation of multiple ceramide species, decreases levels of sphingosine and S1P. |
| PC-25385 |
Ceranib-1
Ceramidase inhibitor
|
Ceranib-1 (Ceranib 1) is a small molecule ceramidase inhibitor, exhibits antiproliferative effect in SKOV3 cells with IC50 of 4.1 uM, induces the accumulation of multiple ceramide species, decreases levels of sphingosine and S1P. |
| PC-25384 |
Acid ceramidase inhibitor 43
Acid ceramidase inhibitor
|
Acid ceramidase inhibitor 43 is a potent, small molecule inhibitor of acid ceramidase (aCDase) with enzymatic pIC50 of 8.5 and cellular pIC50 of 6.8 (A375 melanoma cell). |
| PC-25362 |
Dracorhodin perchlorate
CD147 inhibitor
|
Dracorhodin perchlorate is a potent CD147 inhibitor that induces autophagy-dependent degradation, triggers PUFA/MUFA balance-mediated ferroptosis. |
| PC-25357 |
Avicularin
FOXM1 inhibitor
|
Avicularin is a Chinese herbal medicine with anti-inflammatory and antioxidative effects, reduces cell viability and induces caspase-dependent apoptosis in NSCLC cells by facilitating USP7-dependent degradation of FOXM1. |
| PC-25349 |
hClpP inhibitor TG42
hClpP inhibitor
|
hClpP inhibitor TG42 is a potent and selective inhibitor of hClpP with IC50 of 0.39 uM, efficiently blocks proteolysis. |
| PC-25348 |
AV167
ClpP inhibitor
|
AV167 is a potent, small molecule inhibitor of Caseinolytic protease P (ClpP) with IC50 of 1.54 uM. |
| PC-25347 |
BC8a
hClpP inhibitor
|
BC8a (ClpP inhibitor 8a) is a potent inhibitor of hClpP with IC50 of 10.2 uM, inhibits hClpP peptidase activity, also inhibits the holoenzyme hClpXP. |
| PC-25340 |
Imifoplatin
CAS 1339960-28-9
|
Imifoplatin (PT-112) is the first pyrophosphate-platinum conjugate, causes immunogenic cell death in experimental models, is an immunogenic cell death (ICD)-inducing small molecule, inhibits ribosome biogenesis and causes organelle stresses, leading to selective ICD in cancer cells. |
