| Cat. No. |
Product Name |
Information |
| PC-25817 |
Claudin 5 binder CL5B
CLDN5 binder
|
Claudin 5 binder CL5B is a small molecule binder of Claudin 5 (CLDN5), binds directly to hCLDN5 with KD of 31.7 uM, opens the blood-brain barrier and safely enhances brain drug delivery. |
| PC-25807 |
Ciliogenesis inhibitor Nao-3
Ciliogenesis inhibitor
|
Ciliogenesis inhibitor Nao-3 (Naonedin-3) is specific small-molecule inhibitor of ciliogenesis, represses primary ciliogenesis and induces the death of chemoresistant ciliated stem-like cells. |
| PC-25798 |
YL0441
ΔFOSB inhibitor
|
YL0441 is a highly effective inhibitor of AP1 transcription factor ΔFOSB with IC50 of 13.7 uM and 12.3 uM, disrupts ΔFOSB/JUND and ΔFOSB/ΔFOSB binding to DNA, inhibits AP1-transcription factor-mediated expression of the luciferase reporter gene with IC50 of 0.1 uM. |
| PC-25795 |
ASX-173
Asparagine synthetase inhibitor
|
ASX-173 is a selective, cell-penetrable small molecule inhibitor of human asparagine synthetase (ASNS), inhibits L-asparagine production with IC50 of 0.5 uM,, induces the integrated stress response (ISR), and reduces cell growth in HEK-293A cells. |
| PC-25784 |
ML345
IDE inhibitor, NLRP3 inhibitor
|
ML345 is a potent, selective Insulin-degrading enzyme (IDE, Insulysin) with IC50 of 188 nM, targets a specific cysteine residue (Cys819) in IDE, also is a highly potent and selective NLRP3 inhibitor, directly targets tyrosine 381 (Y381) and disrupts its essential interaction with NIMA-related kinase 7 (NEK7). |
| PC-25765 |
TRF1-TIN2 interaction inhibitor 1
TRF1 inhibitor
|
TRF1-TIN2 interaction inhibitor 1 (Compound 40) is a first-in-class inhibitor of the TRF1:TIN2 interaction with IC50 of 67 uM, binds to TRFH domain of TRF1 (TRF1 TRFH) with KD of 29 uM, disrupts shelterin complex assembly. |
| PC-25748 |
PKSI-527
Plasma kallikrein inhibitor, PLK inhibitor
|
PKSI-527 is a highly selective plasma kallikrein inhibitor, suppresses collagen-induced arthritis (CIA) by modifying the kallikrein-kinin system, also is a selective PLK inhibitor. |
| PC-25741 |
SB-633825
TIE2 inhibitor, STK10 inhibitor
|
SB-633825 is a potent and ATP-competitive inhibitor of TIE2, LOK (STK10) and BRK with IC50s of 3.5 nM, 66 nM, 150 nM, respectively, inhibits cancer cell growth and angiogenesis. |
| PC-25740 |
STK10 inhibitor 23
STK10 inhibitor
|
STK10 inhibitor 23 is a potent, selective inhibitor of STK10 (serine/threonine kinase 10, LOK) with IC50 of 0.85 uM. |
| PC-25732 |
RUVBL1/2 ATPase-IN-1
RUVBL1/RUVBL2 inhibitor
|
RUVBL1/2 ATPase-IN-1 is a small-molecule inhibitor of RUVBL1/2 ATPase with IC50 of 6.0 uM and 7.7 uM against RUVBL1/2 complex and RUVBL1 respectively. |
| PC-25731 |
RUVBL1/RUVBL2 inhibitor Compound B
RUVBL1/RUVBL2 inhibitor
|
RUVBL1/RUVBL2 inhibitor Compound B is a potent, specific and orally bioavailable RUVBL1/2 ATPase (pontin/TIP49 and reptin/TIP48) inhibitor with IC50 of 59 nM. |
| PC-25725 |
PYCR1-IN-1
PYCR1 inhibitor
|
PYCR1-IN-1 (ProPI-1, Proline Production Inhibitor-1) is a small molecule pyrroline-5-carboxylate reductase 1 (PYCR1) inhihibitor with IC50 of 8.8 uM. |
