| Cat. No. |
Product Name |
Information |
| PC-22965 |
KHK inhibitor 14
Ketohexokinase inhibitor
|
KHK inhibitor 14 is a potent ketohexokinase (KHK) inhibitor with IC50 of 59 nM for KHK-A enzymatic assay and IC50 of 196 nM for hepG2 assay. |
| PC-22964 |
BI-9787
Ketohexokinase inhibitor
|
BI-9787 is a potent, selective zwitterionic ketohexokinase (KHK) inhibitor with enzymatic IC50 of 12/12.8 nM (hKHK-A/C), and cellular IC50 of 123 nM in F1P HepG2 assay. |
| PC-22962 |
ABCA1 inducer 39
ABCA1 inducer
|
ABCA1 inducer 39 is a nonlipogenic ABCA1-inducer (NLAI) with EC50 of 0.1 uM, increases ABCA1 expression, enhances APOE lipidation, and reverses multiple AD phenotypes, without increasing triglycerides (TG). |
| PC-22918 |
NAT1 inhibitor Cmp350
NAT1 inhibitor
|
NAT1 inhibitor Cmp350 is a potent small molecule inhibitor of arylamine N-acetyltransferase 1 (NAT1) with IC50 of 44 nM, inhibits mitochondrial respiration and alters mitochondrial metabolism in MDA-MB-231 cells. |
| PC-22916 |
hSR inhibitor 28
Serine racemase inhibitor
|
hSR inhibitor 28 is a potent, selective inhibitor of human serine racemase (SR) with Kd of 5 uM. |
| PC-22915 |
Orziloben
1555822-28-0
|
Orziloben is a novel, orally administered, highly potent, synthetic, medium chain fatty acid analogue (MCFA), shows potential for intestinal failure-associated liver disease (IFALD). |
| PC-22887 |
CD80 inhibitor 6
CD80 inhibitor
|
CD80 inhibitor 6 is a specific small molecule inhibitor of human CD80 with SPR KD of 2.7 nM, antagonize CD28 (TR_FRET EC50=2.4 nM) and CTLA-4 binding to CD80, inhibits the release of the proinflammatory cytokines IL-2, IFNγ, and TNFα at submicromolar doses in T cell costimulation assays. |
| PC-22886 |
CD80 inhibitor 1
CD80 inhibitor
|
CD80 inhibitor 1 is a specific small molecule inhibitor of human CD80 with SPR KD of 125 nM, antagonize CD28 (TR_FRET EC50=630 nM) and CTLA-4 binding to CD80, inhibits the release of the proinflammatory cytokines IL-2, IFNγ, and TNFα at submicromolar doses in T cell costimulation assays. |
| PC-22881 |
DPTIP
nSMase 2 inhibitor
|
DPTIP is a potent brain penetrant neutral sphingomyelinase 2 (N-SMase 2) inhibitor with IC50 of 30 nM. |
| PC-22870 |
12-deoxyphorbol 13-palmitate
APOL2 inhibitor
|
12-deoxyphorbol 13-palmitate is a potent inhibitor of hepatic stellate cell (HSC) activation, directly and specifically targets apolipoprotein L2 (APOL2). |
| PC-22860 |
GZ667161
Glucosylceramide synthase inhibitor
|
GZ667161 (Genz-667161) is potent, orally available and CNS-penetrant inhibitor of Glucosylceramide synthase (GCS), alleviates aberrations in synucleinopathy models. |
| PC-22844 |
LXG6403
LOX inhibitor
|
LXG6403 is a highly potent, irreversible lysyl oxidase (LOX) inhibitor, inhibits cellular LOX activity efficiently in MDA-MB-231 cells with IC50 of 1.3 uM, >3-fold selective over LOXL2 and no activity against LOXL1. |
