| Cat. No. |
Product Name |
Information |
| PC-23813 |
SCR-1481B1
GSDMD inhibitor
|
SCR-1481B1 (Metatinib anhydrous, Compound 68) is a specific small molecule inhibitor of gasdermin D (GSDMD) targeting the GSDMD N-terminal oligomerization interface I (MST KD=0.4 uM), exert pyroptosis inhibitory effects, also shows inhibition on Met activation VEGFR. |
| PC-23808 |
ARC39
Acid sphingomyelinase inhibior
|
ARC39 is a direct, selective acid sphingomyelinase (ASM) inhibitor with IO50 of 20 nM, inhibits both lysosomal and secretory ASM in vitro. |
| PC-23800 |
LFHP-1c
PGAM5 inhibitor
|
LFHP-1c is a direct phosphoglycerate mutase family member 5 (PGAM5) inhibitor with binding SPR KD of 961 nM, not only inhibits the PGAM5 phosphatase activity, but also reduces the interaction of PGAM5 with NRF2. |
| PC-23794 |
KKT3054
KAI2 antagonist
|
KK181N1 is a specific inhibitor of karrikins (KARs) receptor KAI2, selectively inhibits Arabidopsis karrikin signaling, binds to the catalytic pocket of AtKAI2 with Kd of 14.9 uM. |
| PC-23793 |
KK181N1
KAI2 antagonist
|
KK181N1 is a specific inhibitor of karrikins (KARs) receptor KAI2, selectively depresses the KAR-induced phenotypes in Arabidopsis, binds to the catalytic pocket of AtKAI2 with Kd of 27.7 uM. |
| PC-23789 |
PQ529
QC/isoQC inhibitor
|
PQ529 is a selective glutaminyl cyclase (QC, QPCT) / isoenzyme of glutaminyl cyclase (isoQC, QPCTL) inhibitor. |
| PC-23787 |
PFKFB2 inhibitor B2
PFKFB2 inhibitor
|
PFKFB2 inhibitor B2 is a small molecule inhibitor of PFKFB2 (6-Phosphofructo-2-Kinase/Fructose-2,6-Biphosphatase 2) with IC50 of 3.29 uM, inhibits PFKFB3 with IC50 of 11.89 uM. |
| PC-23783 |
BL001
LRH-1 agonist
|
BL001 is a specific small molecule agonist of liver receptor homologue-1 (LRH-1) with EC50 of 0.1 uM, specifically binds to and activates LRH-1. |
| PC-23762 |
SH514
IRF4 inhibitor
|
SH514 is a specific small molecule inhibitor of interferon regulatory factor 4 (IRF4) with IC50 of 2.63 uM, inhibits proliferation of IRF4-high-expressing NCI-H929 and MM.1R MM cells with IC50 of 0.08 uM and 0.11 uM, respectively. |
| PC-23758 |
MTDH-SND1 PPI inhibitor C19
MTDH-SND1 inhibitor
|
MTDH-SND1 PPI inhibitor C19 is a small-molecule inhibitor of MTDH-SND1 PPI with IC50 of 487 nM, directly binds to the SND1-purified protein, degrades SND1 and downregulates downstream at the protein level. |
| PC-23750 |
Dauricine
STK11 agonist
|
Dauricine, a bisbenzylisoquinoline alkaloid in Menispermum dauricum, has anti-inflammatory activity, Dauricine is a natural agonist of STK11 (Serine/threonine kinase 11). |
| PC-23749 |
Benurestat
Urease inhibitor
|
Benurestat is a reversible competitive inhibitor of gut bacterial urease, inhibits ammonia production by urease-encoding gut bacteria, inhibits urease activity in mouse fecal suspensions ex vivo with IC50 of 2.5 uM. |
