| Cat. No. |
Product Name |
Information |
| PC-23519 |
Necrocide-1
Necrosis inducer
|
Necrocide-1 (NC1) is a small molecule inducer of tumor necrosis factor (TNF)-independent necrosis, shows antiproliferative activity with IC50 values of 0.48 and 2 nM for MCF-7 and PC3, respectively |
| PC-23518 |
CNOT6L inhibitor iD1
CNOT6L inhibitor
|
CNOT6L inhibitor iD1 (Inhibitor of CNOT6L Deadenylase 1, ICCB-475) is a specific small molecule inhibitor of CCR4-NOT deadenylase subunit CNOT6L with Kd of 7.6 uM and IC50 of 2.5 uM in FRET-based deadenylase assay, modestly inhibits homolog CNOT6 and does not inhibit CNOT7 or CNOT8. |
| PC-23516 |
BC-DXI-843
AIMP2-DX2 inhibitor
|
BC-DXI-843 is a potent and specific AIMP2-DX2 inhibitor with IC50 og 0.92 uM, >100-fold selectivity over AIMP2. |
| PC-23515 |
VP 21-04
HO-1 inhibitor
|
VP 21-04 is a potent, selective Heme oxygenase-1 (HO-1) inhibitor with IC50 of 0.9 uM, displays 42-fold selective over HO-2 (IC50=38 uM). |
| PC-23509 |
SDL01
AIMP2-DX2 inhibitor, DX2-Siah1 modulator
|
SDL01 is a specific small molecule allosteric modulator / enhancer of the interaction between AIMP2-DX2 (DX2) and Siah1, promotes DX2 degradation by Siah1 with IC50 of 1.09 uM in A549 cells. |
| PC-23501 |
CLPP-1071
ClpP agonist
|
CLPP-1071 is a potent, orally efficacious activator of human sapiens caseinolytic protease P (ClpP) with EC50 of 23.5 nM, exhibits HL60 cell growth inhibition with IC50 of 4.6 nM. |
| PC-23500 |
NCA029
ClpP agonist
|
NCA029 is a potent and selective homo sapiens caseinolytic protease P (HsClpP) activator with EC50 of 0.2 uM. |
| PC-23499 |
SL44
ClpP agonist
|
SL44 is a potent, small molecule activator /agonist of human caseinolytic protease P (HsClpP) with EC50 of 1.3 uM. |
| PC-23498 |
ClpP activator XT6
ClpP agonist
|
ClpP activator XT6 is a potent human caseinolytic protease P (hClpP) activator with EC50 of 0.08 uM, exhibits good antitumor potency. |
| PC-23497 |
ZG111
ClpP agonist
|
ZG111 is a potent ClpP agonist with EC50 of 1.19 uM, binds to ClpP and promotes the ClpP-mediated degradation of respiratory chain complexes. |
| PC-23450 |
UNC10142
CHD1 inhibitor
|
UNC10142 is a first-in-class, specific, cell-active small molecule antagonist of the tandem chromodomains of CHD1 (Chromodomain-Helicase DNA-Binding Protein 1) with binding IC50 of 1.7 uM in TR-FRET assays. |
| PC-23443 |
164A10
Pin1 degrader
|
164A10 is a potent Pin1 destabilizer and degrader with IC50 of 4.1 nM in DELFIA displacement assay, destabilizes Pin1 in vitro and also results more effective in causing Pin1 degradation in cells. |
