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Cat. No. Product Name Information
PC-22607

Orpinolide

OSBP inhibitor

Orpinolide is a synthetic withanolide analog with potent antileukemic properties, directly targets oxysterol-binding protein OSBP, disrupts Golgi homeostasis via a mechanism that requires active phosphatidylinositol 4-phosphate (PtdIns4P, PI4P) signaling at ER-Golgi membrane interface.
PC-22606

SABRAC

Acid ceramidase inhibitor

SABRAC is a highly potent, irreversible inhibitor of acid ceramidase with Ki of 29.7 nM, induces apoptosis and provides a benefit in mice survival in IDH1 mut oligodendroglioma.
PC-22604

Oxybipin-2

OSBP inhibitor

Oxybipin-2 is a potent and selective inhibitor of oxysterol-binding protein (OSBP), inhibits OSBP–22-NBD-Chol interaction with IC50 of 13 nM, impair retrograde trafficking.
PC-22593

UNC10245380

CIB1 inhibitor

UNC10245380 (UNC5380) is a small molecule ligand/inhibitor of Calcium and Integrin Binding protein 1 (CIB1) with IC50 of 8.0 uM in TR-FRET displacement assay, selectively kills CIB1 depletion-sensitive TNBC cells.
PC-22571

TMLB-C16

B3GAT3 inhibitor

TMLB-C16 is a potent beta-1,3-glucuronosyltransferase (B3GAT3) inhibitor with KD of 3.96 uM, suppresses proliferation and migration in HCC cells.
PC-22564

T-10418

GPR132 agonist

T-10418 is a potent, selective agonist of G protein-coupled receptor G2A (GPR132) with EC50 of 0.82 uM.
PC-22541

PSB-KK1445

GPR18 agonist

PSB-KK1445 is a potent and selective GPR18 agonist with EC50 of 45.4 nM and 124 nM for human and mouse GPR18, respectively, shows high selectivity versus related GPCRs CB1 and CB2, cannabinoid-like receptor, GPR55.
PC-22540

YK-4-279

EWS-FLI1 inhibitor

YK-4-279 is a specific small molecule inhibitor of EWS-FLI1 interaction with RNA helicase A with SPR KD of 9.48 uM for EWS-FLI1, reduces EWS-FLI1 functional activity, also reduces EWS-FLI1 modulated transcription.
PC-22489

UR778Br

IQGAP1 inhibitor

UR778Br is a potent small molecule inhibitor of scaffolding protein IQGAP1, taregting the IQGAP1-GRD domain, selectively inhibits growth of human acute myeloid leukemia.
PC-22481

Forchlorfenuron

Septin inhibitor

Forchlorfenuron (CPPU, 4PU30) is a substituted phenylurea compound and synthetic plant cytokinin for inducing somatic embryogenesis in peanut (Arachis hypogaea L.), inhibits septin and protrusion formation.
PC-22470

PW0729

GPR52 agonist

PW0729 is a potent, selective, G protein-biased agonist of orphan GPR52 with EC50 of 47 nM in cAMP assay, Emax=143%.
PC-22469

BI-43

Glutaminyl cyclase inhibitor

BI-43 is a potent, selective glutaminyl cyclase inhibitor with IC50 of 12 nM and 40 nM for both sQC and gQC, respectively.

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