| Cat. No. |
Product Name |
Information |
| PC-23998 |
GJG057
LTC4S inhibitor
|
GJG057 is a potent, selective and orally bioavailable inhibitor of leukotriene C4 synthase (LTC4S) with IC50 of 44 nM in whole blood LTC4 release assay and 14 nM in enzymatic assays. |
| PC-23996 |
ZYS-1
ADAR1 inhibitor
|
ZYS-1 is a potent small-molecule ADAR1 (denosine deaminase acting on RNA 1) inhibitor, suppresses PCa growth and metastasis and potentiated the antitumor immune response. |
| PC-23983 |
AM-3607
GlyR PAM
|
AM-3607 is a potent, positive allosteric modulator of mammalian ionotropic glycine receptor (GlyR) subtypes with EC50 of 25 nM (hGlyRα3β), SPR Kd of 11 nM. |
| PC-23982 |
AM-1488
GlyR PAM
|
AM-1488 is a potent, positive allosteric modulator of mammalian ionotropic glycine receptor (GlyR) subtypes with EC50 of 0.45 uM (hGlyRα3β), SPR Kd of 0.19 uM. |
| PC-23969 |
BPK-21
ERCC3 inhibitor
|
BPK-21 is a specific inhibitor of helicase ERCC3, suppresses T cell activation through blockade of ERCC3 function, targets C342 in ERCC3. |
| PC-23968 |
BPK-25
NuRD inhibitor
|
BPK-25 is a small molecule inhibitor of Nucleosome Remodeling and Deacetylation Complex (NuRD), suppresses T-cell activation at low-μM concentrations without causing cytotoxicity. |
| PC-23950 |
PKRA7
PK2 antagonist
|
PKRA7 (PKRA83) is a potent polypeptide chemokine PK2 (Bv8, PROK2) antagonist, potently inhibit PK2 receptors with IC50 of 5.0 and 8.2 nM for PKR1 and PKR2, respectively. |
| PC-23929 |
CDNB
TrxR inhibitor
|
CDNB is a selective small molecule inhibitor of thioredoxin reductase (TrxR), inhibits TrxR activity with IC50 of 9.4 uM in raw macrophages. |
| PC-23928 |
MitoCDNB
TrxR2 inhibitor
|
MitoCDNB is a mitochondria-targeted molecule that disrupts thiol redox state and inhibits TrxR2, selectively disrupts mitochondrial thiol redox state in cells and in vivo, selectively depletes the mitochondrial GSH pool. |
| PC-23924 |
Nitrobenzylthioinosine
ENT1 inhibitor
|
Nitrobenzylthioinosine (NBMPR) is a specific equilibrative nucleoside transporter 1 (ENT1, SLC29A1)) inhibitor that binds to ENT1 transporter with high affinity. |
| PC-23923 |
Dilazep dihydrochloride
ENT1 inhibitor
|
Dilazep dihydrochloride is a small molecule adenosine reuptake inhibitor (AdoRI) and equilibrative nucleoside transporter 1 (ENT1) inhibitor (Ki=151.4 nM), shows cerebral and coronary vasodilating action through enhancement of effect of adenosine. |
| PC-23917 |
JH-ENT-01
ENT1 inhibitor
|
JH-ENT-01 is a potent, specific inhibitor of the equilibrative nucleoside transporter subtype 1 (ENT1) with Ki of 92.7 nM, shows good selectivity for hENT1 over hENT2. |
