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Pyrimidinone 8

Chemical Structure : Pyrimidinone 8

CAS No.: 65004-42-4

Pyrimidinone 8

Catalog No.: PC-61214Not For Human Use, Lab Use Only.

Pyrimidinone 8 is a novel allosteric, non-competitive divalent metal transporter-1 (SLC11A2/DMT1) inhibitor with Ki of 20 uM.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    Pyrimidinone 8 is a novel allosteric, non-competitive divalent metal transporter-1 (SLC11A2/DMT1) inhibitor with Ki of 20 uM.
    Pyrimidinone 8 does not affect hDMT1 cell surface expression and shows no dependence on extracellular pH.

    Physicochemical Properties

    M.Wt 204.233
    Formula C10H12N4O
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO

    Chemical Name/SMILES

    2-(3,5-dimethyl-1H-pyrazol-1-yl)-6-methylpyrimidin-4(3H)-one

    References

    1. Montalbetti N, et al. Biochem Pharmacol. 2015 Aug 1;96(3):216-24.

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