Pyrimidinone 8 |CAS:65004-42-4 Probechem Biochemicals

Chemical Structure : Pyrimidinone 8

Pyrimidinone 8

Catalog No.: PC-61214Not For Human Use, Lab Use Only.

Pyrimidinone 8 is a novel allosteric, non-competitive divalent metal transporter-1 (SLC11A2/DMT1) inhibitor with Ki of 20 uM.

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Biological Activity

Pyrimidinone 8 is a novel allosteric, non-competitive divalent metal transporter-1 (SLC11A2/DMT1) inhibitor with Ki of 20 uM.
Pyrimidinone 8 does not affect hDMT1 cell surface expression and shows no dependence on extracellular pH.

Physicochemical Properties

M.Wt	204.233
Formula	C10H12N4O
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	2-(3,5-dimethyl-1H-pyrazol-1-yl)-6-methylpyrimidin-4(3H)-one

References

1. Montalbetti N, et al. Biochem Pharmacol. 2015 Aug 1;96(3):216-24.

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Pyrimidinone 8

Biological Activity

Physicochemical Properties

References

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