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AUDA

Chemical Structure : AUDA

CAS No.: 479413-70-2

AUDA (sEH inhibitor)

Catalog No.: PC-70254Not For Human Use, Lab Use Only.

AUDA is a potent inhibitor of sEH (soluble epoxide hydrolase) with IC50 of 18 nM and 69 nM for mouse sEH and human sEH, respectively.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

AUDA is a potent inhibitor of sEH (soluble epoxide hydrolase) with IC50 of 18 nM and 69 nM for mouse sEH and human sEH, respectively.
AUDA activates PPARα 3-fold at a concentration of 10 uM but exhibits no affect on PPARδ or PPARγ.
AUDA decreases mean arterial blood pressure and increases urinary epoxide-to-diol ratios in angiotensin-infused rats.

Physicochemical Properties

M.Wt 392.6
Formula C23H40N2O3
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

12-[[(tricyclo[3.3.1.13,7]dec-1-ylamino)carbonyl]amino]-dodecanoic acid

References

1. Schmelzer KR, et al. Proc Natl Acad Sci U S A. 2006 Sep 12;103(37):13646-51.

2. Morisseau C, et al. Biochem Pharmacol. 2002 May 1;63(9):1599-608.

3. Fang X, et al. J Pharmacol Exp Ther. 2005 Jul;314(1):260-70.

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