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Chemical Structure : Ferristatin II
CAS No.: 1937-37-7
Catalog No.: PC-61208Not For Human Use, Lab Use Only.
Ferristatin II (NSC 8679, NSC8679, Chlorazol Black) is a small molecule iron transport inhibitor that promotes degradation of transferrin receptor-1 in vitro and in vivo, through a nystatin-sensitive lipid raft pathway.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $158 | In stock | |
| 10 mg | $228 | In stock | |
| 25 mg | $368 | In stock | |
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| 100 mg | Get quote |
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Ferristatin II (NSC 8679, NSC8679, Chlorazol Black) is a small molecule iron transport inhibitor that promotes degradation of transferrin receptor-1 in vitro and in vivo, through a nystatin-sensitive lipid raft pathway.
Ferristatin II reduces intestinal (59)Fe uptake, lowers serum iron and transferrin saturation, with no effect on liver non-heme iron stores.
Ferristatin II decreases expression of Smad downstream targets Smad7 and Id1 and increases expression of Stat3 downstream targets, induces hepatic hepcidin expression in vivo and in vitro.
| M.Wt | 781.73 | |
| Formula | C34H25N9Na2O7S2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
4-Amino-3-[[4'-[(2,4-diaminophenyl)azo][1,1'-biphenyl]-4-yl]azo]-5-hydroxy-6-(phenylazo)-2,7-naphthalenedisulfonic acid disodium salt |
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1. Byrne SL, et al. PLoS One. 2013 Jul 23;8(7):e70199.
2. Yanatori I, et al. Cell Biol Int. 2015 Apr;39(4):427-34.
3. Alkhateeb AA, et al. Am J Physiol Gastrointest Liver Physiol. 2015 Jun 15;308(12):G1019-26.
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