| Cat. No. |
Product Name |
Information |
| PC-26619 |
BCAT2-IN-2
BACT2 inhibitor
|
BCAT2-IN-2 is a potent, selective, in-vivo efficacious BCATm (BCAT2) inhibitor with pIC50 of 7.3, 100-fold selective for BCATm over BCATc. |
| PC-26618 |
BCAT2-IN-1
BACT2 inhibitor
|
BCAT2-IN-1 is a potent, selective, in-vivo efficacious BCATm (BCAT2) inhibitor with pIC50 of 7.3, 100-fold selective for BCATm over BCATc. |
| PC-26617 |
BAY-771
BAY-069 control
|
BAY-771 is a negative control compound of dual BCAT1/2 inhibitor BAY-069. |
| PC-26616 |
BAY-252
BACT1/BACT2 inhibitor
|
BAY-252 is a potent branched-chain amino acid transaminases 1 (BCAT1) and BCAT2 inhibitor with IC50s of 2 μM and 2 μM, respectively. |
| PC-26613 |
ERG240
BCAT1 inhibitor
|
ERG240 (ERG-240) is a potent, selective, orally active branched-chain amino acid aminotransferase 1 (BCAT1) inhibitor, inhibits recombinant BCAT1 with an IC50 of 0.1-1 nM, with no inhibition on BCAT2. |
| PC-26585 |
FUBP1-IN-1
FUBP1 inhibitor
|
FUBP1-IN-1 is a small molecule inhibitor of transcriptional regulator FUSE binding protein 1 (FUBP1), inhibits the binding of FUBP1 to the FUSE sequence with IC50 of 11.0 uM, reduces cell expansion and induces of cell death in hepatocellular carcinoma cells. |
| PC-26574 |
Rnaseh2c-In1
Rnaseh2c inhibitor
|
Rnaseh2c-In1 is a specific small molecule inhibits of ribonuclease H2 subunit C (Rnaseh2c), significantly inhibits the proliferation of HCC via Cdk9 proliferation axis and CCL2/CCR2-mediated CD8+ Tex infiltration. |
| PC-26567 |
ELMO2 inhibitor C52
ELMO2 inhibitor
|
ELMO2 inhibitor C52 is a specific small-molecule Engulfment and cell motility 2 (ELMO2) inhibitor, binds to ELMO2 with a dissociation constant (KD) of 1.0 uM, effectively kills ELMO3-low lung cancer cells and EGFR inhibitor-resistant cells. |
| PC-26552 |
BTdCPU
HRI activator
|
BTdCPU is a potent activator of heme-regulated inhibitor (HRI) eIF2α kinase that promotes eIF2α phosphorylation and induces apoptosis in Dexamethasone-resistant cancer cells. |
| PC-26548 |
SOD1 stabilizer C7
SOD1 binder
|
SOD1 stabilizer C7 is a SOD1-stabilizing small molecule preferentially bound the native-like conformation of SOD1, inhibits irreversible apo-SOD1 misfolding in vitro. |
| PC-26503 |
Z1149421873
NAP1L1 inhibitor
|
Z1149421873 (Z11) is a small-molecule inhibitor of NAP1L1 with SPR Kd value of 7.86 nM, inhibits its protein expression in vitro and exerts anti-fibrotic effects in PMCFs. |
| PC-26502 |
SARM1 inhibitor 19
SARM1 inhibitor
|
SARM1 inhibitor 19 is a potent, selective and orally bioavailable SARM1 inhibitor with pIC50 of 7.1 (hSARM1), protect primary rat and mouse DRGs treated with vincristine with EC50 of 55 nM and 113 nM respectively. |
