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JYQ-164

Chemical Structure : JYQ-164

CAS No.:

JYQ-164 (JYQ164)

Catalog No.: PC-22305Not For Human Use, Lab Use Only.

JYQ-164 (JYQ164) is a potent, highly selective Parkinson disease protein 7 (PARK7/DJ-1) inhibitor with IC50 of 21 nM, binds covalently and selectively to PARK7 Cys106.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

JYQ-164 (JYQ164) is a potent, highly selective Parkinson disease protein 7 (PARK7/DJ-1) inhibitor with IC50 of 21 nM, binds covalently and selectively to PARK7 Cys106.

Physicochemical Properties

M.Wt 530.62
Formula C23H26N6O5S2
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

(R)-1-Cyano-N-(5-(3-(morpholinosulfonyl)benzoyl)-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridin-2-yl)pyrrolidine-3-carboxamide

References

1. Jia Y, et al. J Med Chem. 2024 May 7. doi: 10.1021/acs.jmedchem.3c02410.

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