Chemical Structure : PRDX1 inhibitor H7
CAS No.:
1815599-24-6
PRDX1 inhibitor H7
(Peroxiredoxin I inhibitor H7)
Catalog No.: PC-22248Not For Human Use, Lab Use Only.
PRDX1 inhibitor H7 is a specific small molecule inhibitor of antioxidant enzyme peroxiredoxin I (Prdx I) with IC50 of 7.85 uM, induces leukemia-cell differentiation in vitro and in vivo.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
PRDX1 inhibitor H7 is a specific small molecule inhibitor of antioxidant enzyme peroxiredoxin I (Prdx I) with IC50 of 7.85 uM, induces leukemia-cell differentiation in vitro and in vivo.
H7 directly and non-covalently binds to Prdx I but not to Prdxs II-V in cells.
Knockdown or overexpression of Prdx I increases or decreases H7-induced cell differentiation, H7 induces partial differentiation of NB4 cells.
H7 induces cell differentiation of non-APL leukemia cell lines and primary cells, through activation of the ROS-Erk1/2-C/EBPβ pathway.
H7 (10 mg/kg, 20 mg/kg, introperitoneal) daily for 5 consecutive days induced leukemia-cell differentiation in APL leukemic mice.
Physicochemical Properties
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M.Wt
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325.38
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Formula
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C18H15NO3S
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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(E)-4-ethyl-N-(4-oxonaphthalen-1(4H)-ylidene)benzenesulfonamide
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References
1. Wei Wei, et al. Oncotarget. 2016 Jan 26;7(4):3873-83.
2. Wirakiat W, et al. Life Sci. 2020 Oct 1;258:118227.
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