PRDX1 inhibitor 15

Chemical Structure : PRDX1 inhibitor 15

Catalog No.: PC-22249Not For Human Use, Lab Use Only.

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Biological Activity

PRDX1 inhibitor 15 is a potent, selective and covalent peroxiredoxin (PRDX1) inhibitor with IC50 of 0.35 uM, covalently binds to Cys-173 of PRDX1 with KD of 0.37 uM, shows antiproliferative potency against colon cancer cells.
PRDX1 inhibitor 15 displays weak inhibitory effects on PRDX2-PRDX6.
PRDX1 inhibitor 15 dose-dependently decreased the mitochondria membrane potential of SW620 cells, probably due to ROS induced by PRDX1 inhibition, leading to cell apoptosis.
PRDX1 inhibitor 15 displayed potent antitumor efficacy with superior safety to celastrol. colorectal cancer cell xenograft model.

Physicochemical Properties

M.Wt	576.78
Formula	C35H48N2O5
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	Methyl 1-(3-((2R,4aS,6aS,12bR,14aS,14bR)-10-Hydroxy-2,4a,6a,9,12b,14a-hexa-methyl-11-oxo-1,2,3,4,4a,5,6,6a,11,12b,13,14,14a,14b-tetradecahydropicen-2-yl)urei-do)cyclobutane-1-carboxylate

References

1. Yang Li, et al. J Med Chem. 2024 Apr 28. doi: 10.1021/acs.jmedchem.4c00023.