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Chemical Structure : FCW393
Catalog No.: PC-22240Not For Human Use, Lab Use Only.
FCW393 is a potent, selective sialyltransferase inhibitor with IC50 of 7.8 uM and 9.48 uM for ST6GAL1 and ST3GAL3, does not inhibit ST3GAL1 and ST8SIA4 (IC50>100 uM), suppresses cancer metastasis.
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FCW393 is a potent, selective sialyltransferase inhibitor with IC50 of 7.8 uM and 9.48 uM for ST6GAL1 and ST3GAL3, does not inhibit ST3GAL1 and ST8SIA4 (IC50>100 uM), suppresses cancer metastasis.
FCW393 inhibits, in a dose-dependent manner, the α-2,3- and α-2,6-sialyation of integrin isoforms αv, β1, β3, β4, and β5 in MDA-MB-231 cells.
FCW393 displays IC50 of 2.6 μM for the inhibition of MDA-MB-231 cell migration.
FCW393 reduces integrin sialylation in breast cancer and melanoma cells dose-dependently and downregulates proteins associated with the integrin-regulated FAK/paxillin and GEF/Rho/ROCK pathways, and with the VEGF-regulated Akt/NFκB/HIF-1α pathway.
FCW393 reduces tumor size, angiogenesis, and metastatic potential in tumor-bearing mice.
| M.Wt | 810.95 | |
| Formula | C40H58N8O10 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Han-En Tsai, et al. Int J Mol Sci. 2024 Apr 12;25(8):4283.
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