FCW393 | Sialyltransferase inhibitor | Probechem Biochemicals

Chemical Structure : FCW393

FCW393 (FCW-393)

Catalog No.: PC-22240Not For Human Use, Lab Use Only.

FCW393 is a potent, selective sialyltransferase inhibitor with IC50 of 7.8 uM and 9.48 uM for ST6GAL1 and ST3GAL3, does not inhibit ST3GAL1 and ST8SIA4 (IC50>100 uM), suppresses cancer metastasis.

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Biological Activity

FCW393 is a potent, selective sialyltransferase inhibitor with IC50 of 7.8 uM and 9.48 uM for ST6GAL1 and ST3GAL3, does not inhibit ST3GAL1 and ST8SIA4 (IC50>100 uM), suppresses cancer metastasis.
FCW393 inhibits, in a dose-dependent manner, the α-2,3- and α-2,6-sialyation of integrin isoforms αv, β1, β3, β4, and β5 in MDA-MB-231 cells.
FCW393 displays IC50 of 2.6 μM for the inhibition of MDA-MB-231 cell migration.
FCW393 reduces integrin sialylation in breast cancer and melanoma cells dose-dependently and downregulates proteins associated with the integrin-regulated FAK/paxillin and GEF/Rho/ROCK pathways, and with the VEGF-regulated Akt/NFκB/HIF-1α pathway.
FCW393 reduces tumor size, angiogenesis, and metastatic potential in tumor-bearing mice.

Physicochemical Properties

M.Wt	810.95
Formula	C40H58N8O10
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(S)-4-(((3R,5R,8R,9S,10S,13R,14S,17R)-17-((R)-5-(2-(2-(2-azidoethoxy)ethoxy)ethoxy)-5-oxopentan-2-yl)-10,13-dimethylhexadecahydro-1H-cyclopenta[a]phenanthren-3-yl)amino)-3-((7-nitrobenzo[c][1,2,5]oxadiazol-4-yl)amino)-4-oxobutanoic acid

References

1. Han-En Tsai, et al. Int J Mol Sci. 2024 Apr 12;25(8):4283.

FCW393 (FCW-393)

Biological Activity

Physicochemical Properties

References

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