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Leflunomide

Chemical Structure : Leflunomide

CAS No.: 75706-12-6

Leflunomide (HWA486, RS-34821, SU101)

Catalog No.: PC-22222Not For Human Use, Lab Use Only.

Leflunomide is a potent dihydroorotate dehydrogenase (DHODH) and pyrimidine synthesis inhibitor with IC50 of 208.5 nM in cell-free human DHODH enzyme inhibition assays.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

Leflunomide is a potent dihydroorotate dehydrogenase (DHODH) and pyrimidine synthesis inhibitor with IC50 of 208.5 nM in cell-free human DHODH enzyme inhibition assays.

Physicochemical Properties

M.Wt 270.21
Formula C12H9F3N2O2
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

5-Methyl-N-(4-(trifluoromethyl)phenyl)isoxazole-4-carboxamide

References

1. Ola A Elgamal, et al. JCI Insight. 2024 Apr 22;9(8):e173646.

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