Leflunomide | DHODH inhibitor | Probechem Biochemicals

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Chemical Structure : Leflunomide

CAS No.: 75706-12-6

Leflunomide (HWA486, RS-34821, SU101)

Catalog No.: PC-22222Not For Human Use, Lab Use Only.

Leflunomide is a potent dihydroorotate dehydrogenase (DHODH) and pyrimidine synthesis inhibitor with IC50 of 208.5 nM in cell-free human DHODH enzyme inhibition assays.

Packing	Price	Stock
50 mg	$58	In stock
100 mg	$88	In stock
250 mg	$138	In stock
500 mg	$228	In stock
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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

Leflunomide is a potent dihydroorotate dehydrogenase (DHODH) and pyrimidine synthesis inhibitor with IC50 of 208.5 nM in cell-free human DHODH enzyme inhibition assays.

Physicochemical Properties

M.Wt	270.21
Formula	C12H9F3N2O2
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	5-Methyl-N-(4-(trifluoromethyl)phenyl)isoxazole-4-carboxamide

References

1. Ola A Elgamal, et al. JCI Insight. 2024 Apr 22;9(8):e173646.

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Leflunomide (HWA486, RS-34821, SU101)

Biological Activity

Physicochemical Properties

References

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