| Cat. No. |
Product Name |
Information |
| PC-22222 |
Leflunomide
DHODH inhibitor
|
Leflunomide (HWA486, RS-34821, SU101) is a potent dihydroorotate dehydrogenase (DHODH) and pyrimidine synthesis inhibitor with IC50 of 208.5 nM in cell-free human DHODH enzyme inhibition assays. |
| PC-22220 |
HOSU-53 acid
DHODH inhibitor
|
HOSU-53 acid is selective and potent dihydroorotate dehydrogenase (DHODH) inhibitor with IC50 of 0.95 nM in cell-free human DHODH enzyme inhibition assays. |
| PC-22206 |
UNC-CA2-103
TLK2 inhibitor
|
UNC-CA2-103 is a potent, selective tousled like kinase 2 (TLK2) inhibitor with enzyme IC50 of 18 nM, exhibit excellent selectivity over TLK1 (16% inhibition at 0.5 μM). |
| PC-22184 |
Tacrolimus
FKBP ligand
|
Tacrolimus (FK506) is a macrocyclic lactone that binds to FK506 binding protein (FKBP) to form a complex, inhibits calcineurin phosphatase, which inhibits T-lymphocyte signal transduction and IL-2 transcription, shows immunosuppressive properties. |
| PC-22176 |
SMS121
CD36 inhibitor
|
SMS121 (SMS-121) is a drug-like small molecule inhibitor of the very long/long chain fatty acid transporter CD36 (FAT, scavenger receptor class B member 3/SCARB3) with binding Kd of 5.57 uM. |
| PC-22161 |
Triacsin C
ACSL inhibitor
|
Triacsin C (WS 1228A) is an inhibitor of long fatty acid acyl-CoA synthetase (ACSL) with IC50 of 6.3 μM in Raji cells, inhibits TAG accumulation into lipid droplets (LD). |
| PC-22137 |
HYPE inhibitor I2.10
HYPE inhibitor
|
HYPE inhibitor I2.10 is a small molecule HYPE (Huntingtin Yeast Interacting Partner E, FICD) enzyme inhibitor with IC50 of 12.1 uM, inhibits HYPE-mediated AMPylation of BiP in vtro. |
| PC-22060 |
Ternatin-4
eEF1A inhibitor
|
Ternatin-4 is a small molecule elongation factor-1alpha (eEF1A) inhibitor, triggers the ubiquitination and degradation of eEF1A on stalled ribosomes, targets the complex of eEF1A bound to aminoacyl-tRNAs (aa-tRNA). |
| PC-22049 |
ST80
OTUD4-CD73 inhibitor
|
ST-80 is a specific small molecule inhibitor of interaction between CD73 and OTUD4, specifically disrupts proteolytic interaction between CD73 and OTUD4, leading to reinvigoration of cytotoxic CD8+ T cell activities. |
| PC-22048 |
SCD-19
MIF inhibitor
|
SCD-19 is a small molecule migration inhibitory factor (MIF) inhibitor, blocks the induction of pro-inflammatory M1-like phenotype in BMDMs. |
| PC-22011 |
ZZW-115 hydrochloride
NUPR1 inhibitor
|
ZZW-115 (ZZW115) hydrochloride is a potent inhibitor of NUPR1 (Kd=2.1 uM), an intrinsically disordered protein (IDP) with an entirely disordered conformation. |
| PC-21998 |
AANAT inhibitor 1
AANAT inhibitor
|
AANAT inhibitor 1 (N-bromoacetyltryptamine) is a highly potent arylalkylamine N-acetyltransferase (AANAT) inhibitor with IC50 of 500 nM, covalently reacts with AANAT product CoASH. |
