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Cat. No. Product Name Information
PC-38482

CYM2503

GalR2 PAM

CYM2503 is a putative galanin receptors type 2 (GalR2) positive allosteric modulator, concentration-dependently potentiates galanin (100 nM) stimulated IP1 accumulation in HEK293-GalR2 cells with EC50 of 0.69 uM, efficacy of 9.7-fold potentiation.
PC-38478

KYP-2047

Prolyl oligopeptidase (PREP) inhibitor

KYP-2047 is a high affinity prolyl oligopeptidase (PREP) inhibitor with Ki of 0.023 nM, reduces α-synuclein protein levels and aggregates in cellular and animal models of PD.
PC-38445

ML180

LRH1 (NR5A2) inhibitor

ML180 (SR1848) is a potent, selective Liver Receptor Homologue-1 (LRH1, NR5A2) inverse agonist with IC50 of 3.7 uM in reporter assays, displays no activity against SF1 (NR5A1).
PC-38444

ML179

LRH1 (NR5A2) inhibitor

ML179 (SR1309) is a potent, selective Liver Receptor Homologue-1 (LRH1, NR5A2) inverse agonist with IC50 of 320 nM in reporter assays, displays no activity against SF1 (NR5A1).
PC-38436

NEK7 inhibitor M12

NEK7 inhibitor

NEK7 inhibitor M12 is a novel potent inhibitor of NEK7 protein, inhibits cell viability of human HepG2 liver cancer cells.
PC-38425

Utreloxastat

α-synuclein inhibitor

Utreloxastat is a small molecule with potential for suppressing and treating α-synucleinopathies, tauopathies, and other disorders.
PC-38422

Sirpiglenastat

Glutamine antagonist

DRP-104 (Sirpiglenastat) is a novel broad acting glutamine antagonist, has significant anticancer activity by directly targeting tumor metabolism and simultaneously inducing a potent antitumor immune response.
PC-38412

Phevamine A

Virulence factor

Phevamine A is a widely distributed virulence factor in phytopathogens, Phevamine A promotes bacterial growth by suppressing plant immune responses.
PC-38411

BRD8518

TRIB1 inducer

BRD8518 is a specific small molecule TRIB1 inducer, modulates expression of the key genes involved in VLDL production and in LDL clearance in HepG2 cells.
PC-38410

BRD0418

TRIB1 inducer

BRD0418 is a specific small molecule that upregulate TRIB1 expression and phenocopy the effects of TRIB1 cDNA overexpression (EC50=1 uM, TRIB1 overexpression in HepG2 cells).
PC-38407

RJW100

LRH-1 (NR5A2) agonist

RJW100 (RJW 100) is a phospholipid mimetic as liver receptor homolog-1 (LRH-1, NR5A2) agonist with pEC50 of 6.6 and 7.5 for (LRH-1) and steroidogenic factor-1 (SF-1, NR5A1), respectively.
PC-38400

Inaxaplin

APOL1 inhibitor

Inaxaplin (VX-147, VX147) is a small molecule inhibitor of apolipoprotein L1 (APOL1) channel function, shows potential for treatment of proteinuric kidney disease.

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