Catalog No.: PC-49041Not For Human Use, Lab Use Only.
AC-73 is a potent, specific small molecule inhibitor of CD147 (Response Units=63, SPR assays), AC-73 disrupts CD147 dimerization and inhibits the motility and invasion of hepatocellular carcinoma cells.
AC-73 is a potent, specific small molecule inhibitor of CD147 (Response Units=63, SPR assays), AC-73 disrupts CD147 dimerization and inhibits the motility and invasion of hepatocellular carcinoma cells.
AC-73 significantly decreased the migration ability of SMMC-7721 cells in a dose-dependent manner in in vitro scratch assays, decreased the invasion of HCC cells with IC50 of 10.19 μM for SMMC-7721 and 7.16 μM for Huh-7, respectively.
AC-73 inhibits the invasion of HCC cells by reducing MMP-2 production through blocking CD147-stimulated MAPK/STAT3 signaling.
AC-73 (25 mg/kg, 50 mg/kg, intrahepatic injection) reduced tumor metastasis by affecting the CD147/ERK1/2/STAT3 pathways in orthotopic HCC transplant nude mouse model, with low toxicity and well tolerance in nude mice.
AC-73 likely binds to the dimer interface of CD147, the N-terminal IgC2 domain of CD147.
