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Chemical Structure : ASR352
Catalog No.: PC-49085Not For Human Use, Lab Use Only.
ASR352 is a small molecule NSC30049 analog, inhibits the growth of CRC bulk cells, sensitizs FOLFOX-resistant cells, and reduces the sphere formation capacity of CRC stem cells.
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ASR352 is a small molecule NSC30049 analog, inhibits the growth of CRC bulk cells, sensitizs FOLFOX-resistant cells, and reduces the sphere formation capacity of CRC stem cells.
The mechanism of cytotoxicity for ASR352 includes abrogation of 5-FU-induced the S phase, reduction of the phosphorylation of Chk1 at S317P, S345P and S296P, increased γH2AX staining, activation of caspase 3/PARP1 cleavage, and enhancement of Bax/Bcl2 ratio.
| M.Wt | 306.838 | |
| Formula | C16H23ClN4 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Satya Narayan, et al. Eur J Med Chem. 2019 Jan 1;161:456-467.
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