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ASR352

Chemical Structure : ASR352

CAS No.: 2288792-51-6

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ASR352 (ASR 352, ASR-352)

Catalog No.: PC-49085Not For Human Use, Lab Use Only.

ASR352 is a small molecule NSC30049 analog, inhibits the growth of CRC bulk cells, sensitizs FOLFOX-resistant cells, and reduces the sphere formation capacity of CRC stem cells.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    ASR352 is a small molecule NSC30049 analog, inhibits the growth of CRC bulk cells, sensitizs FOLFOX-resistant cells, and reduces the sphere formation capacity of CRC stem cells.
    The mechanism of cytotoxicity for ASR352 includes abrogation of 5-FU-induced the S phase, reduction of the phosphorylation of Chk1 at S317P, S345P and S296P, increased γH2AX staining, activation of caspase 3/PARP1 cleavage, and enhancement of Bax/Bcl2 ratio.

    Physicochemical Properties

    M.Wt 306.838
    Formula C16H23ClN4
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20°C 12 Months; 4°C 6 Months
    In Solvent
    -80°C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    (E)-1-(4-phenylbut-2-en-1-yl)-1,3,5,7-tetraazaadamantan-1-ium chloride

    References

    1. Satya Narayan, et al. Eur J Med Chem. 2019 Jan 1;161:456-467.

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