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NP-C86

Chemical Structure : NP-C86

CAS No.: 2101640-36-0

NP-C86 (GAS5 inhibitor NP-C86)

Catalog No.: PC-49043Not For Human Use, Lab Use Only.

NP-C86 is a small molecule that limits the degradation of GAS5 by blocking the interaction of long noncoding RNA (lncRNA) GAS5 and UPF1. NP-C86 binds to GAS5 with high affinity (Kd=153 nM) and stabilize GAS5 levels in vivo.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

NP-C86 is a small molecule that limits the degradation of GAS5 by blocking the interaction of long noncoding RNA (lncRNA) GAS5 and UPF1. NP-C86 binds to GAS5 with high affinity (Kd=153 nM) and stabilize GAS5 levels in vivo.
NP-C86 (20 nM, 24 hours) dramatically reduces (4-fold) the association between UPF1 and GAS5, increases GAS5 levels and glucose uptake in diabetes mellitus (DM) adipocytes.
NP-C86 is specific for lncRNA GAS5, does not affect levels of MALAT1 or NEAT1, the other lncRNAs present in the adipocytes.
NP-C86 restores insulin-mediated glucose uptake in DM adipocytes.

Physicochemical Properties

M.Wt 1225.605
Formula C68H92N10O9S
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

References

1. Yan Shi, et al. Cell Chem Biol. 2019 Mar 21;26(3):319-330.e6.

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