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Chemical Structure : MS21570
CAS No.: 65373-29-7
Catalog No.: PC-49001Not For Human Use, Lab Use Only.
MS 21570 (MS0021570) is a small molecule antagonist of GPR171, antagonizes MS0015203 (Cat#PC-47110)-mediated increases in [35S]GTPγS binding in rat hypothalamic membranes (EC50 =0.6 nM).
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|---|---|---|---|
| 10 mg | $88 | In stock | |
| 25 mg | $148 | In stock | |
| 50 mg | $248 | In stock | |
| 100 mg | Get quote |
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MS 21570 (MS0021570) is a small molecule antagonist of GPR171, antagonizes MS0015203 (Cat#PC-47110)-mediated increases in [35S]GTPγS binding in rat hypothalamic membranes (EC50 =0.6 nM).
MS 21570 blocked BigLEN-mediated activation of GPR171 in heterologous cells.
MS 21570 inhibited BigLEN-mediated hyperpolarization of BLA pyramidal neurons.
MS 21570 inhibited feeding induced by DREADD-mediated activation of BigLEN containing AgRP neurons in the arcuate nucleus.
MS 21570 significantly attenuated BigLEN-mediated decreases in intracellular cAMP levels.
MS 21570 (5 mg/kg, i.p) decreases anxiety-like behaviors, but not depression and fear in vivo.
| M.Wt | 237.35 | |
| Formula | C10H11N3S2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
5-(benzylthio)-N-methyl-1,3,4-thiadiazol-2-amine |
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1. Erin N Bobeck, et al. Neuropsychopharmacology. 2017 Dec;42(13):2527-2536.
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