Catalog No.: PC-49001Not For Human Use, Lab Use Only.
MS 21570 (MS0021570) is a small molecule antagonist of GPR171, antagonizes MS0015203 (Cat#PC-47110)-mediated increases in [35S]GTPγS binding in rat hypothalamic membranes (EC50 =0.6 nM).
MS 21570 (MS0021570) is a small molecule antagonist of GPR171, antagonizes MS0015203 (Cat#PC-47110)-mediated increases in [35S]GTPγS binding in rat hypothalamic membranes (EC50 =0.6 nM).
MS 21570 blocked BigLEN-mediated activation of GPR171 in heterologous cells.
MS 21570 inhibited BigLEN-mediated hyperpolarization of BLA pyramidal neurons.
MS 21570 inhibited feeding induced by DREADD-mediated activation of BigLEN containing AgRP neurons in the arcuate nucleus.
MS 21570 significantly attenuated BigLEN-mediated decreases in intracellular cAMP levels.
MS 21570 (5 mg/kg, i.p) decreases anxiety-like behaviors, but not depression and fear in vivo.
Physicochemical Properties
M.Wt
237.35
Formula
C10H11N3S2
Appearance
Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility
10 mM in DMSO
Chemical Name/SMILES
5-(benzylthio)-N-methyl-1,3,4-thiadiazol-2-amine
References
1. Erin N Bobeck, et al. Neuropsychopharmacology. 2017 Dec;42(13):2527-2536.
