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PSB-CB5

Chemical Structure : PSB-CB5

CAS No.: 1627710-30-8

PSB-CB5 (GPR18 antagonist PSB-CB5)

Catalog No.: PC-49028Not For Human Use, Lab Use Only.

PSB-CB5 is a potent, selective antagonist of GPR18, inhibits GPR18 activation by tetrahydrocannabinol (THC) with IC50 of 279 nM in β-arrestin recruitment assays.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

PSB-CB5 is a potent, selective antagonist of GPR18, inhibits GPR18 activation by tetrahydrocannabinol (THC) with IC50 of 279 nM in β-arrestin recruitment assays.
PSB-CB5 exhibits >36-fold selectivity versus CB1 and GPR55 and 14-fold selectivity versus CB2 receptors.
PSB-CB5 inhibits N-Arachidonylglycine induced acrosomal exocytosis in human spermatozoa.

Physicochemical Properties

M.Wt 384.878
Formula C20H17ClN2O2S
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

(Z)-2-(3-(4-chlorobenzyloxy)benzylidene)-6,7-dihydro-2H-imidazo [2,1-b][1,3]thiazin-3(5H)-one

References

1. Schoeder CT, et al. Eur J Med Chem. 2018 Jul 15;155:381-397.

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