| Cat. No. |
Product Name |
Information |
| PC-49336 |
JBSNF-000028
NNMT inhibitor
|
JBSNF-000028 (JBSNF000028) is a potent, selective, orally bioavailable substrate-analog inhibitor of nicotinamide N-methyltransferase (NNMT) with IC50 of 34 nM, 190 and 210 nM against human, monkey and mouse NNMT, respectively. |
| PC-49332 |
4-Sulfocalix[8]arene hydrate
AIM2 inhibitor
|
4-Sulfonic calix[8]arene is a potent AIM2 inflammasome inhibitor that work by binding competitively to the DNA binding site, dose dependently inhibits AIM2-dependent cell death and IL-1β release. |
| PC-49331 |
4-Sulfocalix[6]arene hydrate
AIM2 inhibitor
|
4-Sulfonic calix[6]arene is a potent AIM2 inflammasome inhibitor that work by binding competitively to the DNA binding site, dose dependently inhibits AIM2-dependent cell death and IL-1β release. |
| PC-49319 |
SARM1 inhibitor NB-3
SARM1 inhibitor
|
SARM1 inhibitor NB-3 is a small molecule inhibitor of the nicotinamide adenine dinucleotide (NAD) hydrolase SARM1, targets the NAD-dependent active-site by intercepting NAD hydrolysis and undergoing covalent conjugation with the reaction product adenosine diphosphate ribose (ADPR). |
| PC-49318 |
TK106
SARM1 inhibitor, Calmodulin antagonist
|
TK106 (Calmidazolium chloride) is a small molecule non-competitive inhibitor of hSARM1 with IC50 of 10.8 uM, induces and promotes the formation of SARM1 octamers, also binds to calmodulin with a Kd of 3 nM. |
| PC-49293 |
JI130
Hes1 inhibitor
|
JI130 (JI 130) is a small molecule inhibitor of the cancer-associated transcription factor Hes1, targets prohibitin 2 (PHB2) and blocks Hes1-PHB2 interaction, JI130 inhibits MIA PaCa-2 cell growth with EC50 of 49 nM. |
| PC-49289 |
AZD4831
Myeloperoxidase inhibitor
|
AZD4831 (Mitiperstat, AZD-4831) is a potent, selective and irreversible inhibitor of myeloperoxidase (MPO) with IC50 of 1.5 nM, >450-fold vs thyroid peroxidase in vitro. |
| PC-49281 |
IL17A inhibitor 10
IL17A inhibitor
|
IL17A inhibitor 10 is a potent and selective, cell-active inhibitor of IL17A C-terminal region with high binding affinity (SPR KD=43 nM), shows inhibition of IL17A/IL7RA-Fc interactions with IC50 of 740 nM. |
| PC-49279 |
RUNX1/ETO inhibitor 7.44
RUNX1-ETO inhibitor
|
RUNX1-ETO inhibitor 7.44 is a first-in-class, small-molecule inhibitor of RUNX1/ETO tetramerization, specifically interferes the nervy homology region 2 (NHR2) domain of ETO mediating tetramerization with Klig value of 3.75 uM. |
| PC-49276 |
CRCD2
NT5C2 inhibitor
|
CRCD2 is a first-in-class specific small molecule inhibitor of the cytosolic 5' nucleotidase II (NT5C2), directly binds to NT5C2 R367Q recombinant protein with KD of 70.9 uM, shows broadly activies against leukemias bearing highly prevalent relapse-associated mutant forms of NT5C2 in vitro and in vivo. |
| PC-49271 |
MY-9B
SARM1 inhibitor
|
MY-9B is a selective, allosteric and covalent inhibitor of sterile alpha toll/interleukin receptor motif containing-1 (SARM1) with IC50 of 1.2 uM, site-specifically and stereoselectively modify cysteine-311 (C311) in the noncatalytic, autoregulatory armadillo repeat (ARM) domain of SARM1. |
| PC-49270 |
WX-02-37
SARM1 inhibitor
|
WX-02-37 is a selective, allosteric and covalent inhibitor of sterile alpha toll/interleukin receptor motif containing-1 (SARM1) with IC50 of 1.5 uM, site-specifically and stereoselectively modify cysteine-311 (C311) in the noncatalytic, autoregulatory armadillo repeat (ARM) domain of SARM1. |
