| Cat. No. |
Product Name |
Information |
| PC-49379 |
BDK inhibitor BT3
BDK inhibitor
|
BDK inhibitor BT3 is a small molecule allosteric inhibitor of BCKDC kinase (BDK). |
| PC-49378 |
BDK inhibitor BT2
BDK inhibitor
|
BDK inhibitor BT2 is a small molecule allosteric inhibitor of BCKDC kinase (BDK, branched-chain ketoacid dehydrogenase kinase) with IC50 of 3.19 uM. |
| PC-49370 |
GCN2 inhibitor 39
GCN2 inhibitor
|
GCN2 inhibitor 39 is a highly potent and selective, orally active inhibitor of general control nonderepressible 2 (GCN2) with IC50 of 5 nM. |
| PC-49359 |
PXS-4787
pan-LOX inhibitor
|
PXS-4748 (PXS4748) is a potent, selective and irreversible pan-lysyl oxidase (pan-LOX) inhibitor with IC50 of 2.0 uM and 3.2/0.6/1.4/0.2 uM for bovine (aorta) LOX and rh LOXL1/2/3/4, respectively. |
| PC-49358 |
PXS-6302
pan-LOX inhibitor
|
PXS-6302 (PXS6302) is a potent, irreversible pan-lysyl oxidase (pan-LOX) inhibitor with IC50 of 3.7 uM and 3.4/0.4/1.5/0.3 uM for bovine (aorta) LOX and rh LOXL1/2/3/4, respectively. |
| PC-49336 |
JBSNF-000028
NNMT inhibitor
|
JBSNF-000028 (JBSNF000028) is a potent, selective, orally bioavailable substrate-analog inhibitor of nicotinamide N-methyltransferase (NNMT) with IC50 of 34 nM, 190 and 210 nM against human, monkey and mouse NNMT, respectively. |
| PC-49332 |
4-Sulfocalix[8]arene hydrate
AIM2 inhibitor
|
4-Sulfonic calix[8]arene is a potent AIM2 inflammasome inhibitor that work by binding competitively to the DNA binding site, dose dependently inhibits AIM2-dependent cell death and IL-1β release. |
| PC-49331 |
4-Sulfocalix[6]arene hydrate
AIM2 inhibitor
|
4-Sulfonic calix[6]arene is a potent AIM2 inflammasome inhibitor that work by binding competitively to the DNA binding site, dose dependently inhibits AIM2-dependent cell death and IL-1β release. |
| PC-49319 |
SARM1 inhibitor NB-3
SARM1 inhibitor
|
SARM1 inhibitor NB-3 is a small molecule inhibitor of the nicotinamide adenine dinucleotide (NAD) hydrolase SARM1, targets the NAD-dependent active-site by intercepting NAD hydrolysis and undergoing covalent conjugation with the reaction product adenosine diphosphate ribose (ADPR). |
| PC-49318 |
TK106
SARM1 inhibitor, Calmodulin antagonist
|
TK106 (Calmidazolium chloride) is a small molecule non-competitive inhibitor of hSARM1 with IC50 of 10.8 uM, induces and promotes the formation of SARM1 octamers, also binds to calmodulin with a Kd of 3 nM. |
| PC-49293 |
JI130
Hes1 inhibitor
|
JI130 (JI 130) is a small molecule inhibitor of the cancer-associated transcription factor Hes1, targets prohibitin 2 (PHB2) and blocks Hes1-PHB2 interaction, JI130 inhibits MIA PaCa-2 cell growth with EC50 of 49 nM. |
| PC-49289 |
AZD4831
Myeloperoxidase inhibitor
|
AZD4831 (Mitiperstat, AZD-4831) is a potent, selective and irreversible inhibitor of myeloperoxidase (MPO) with IC50 of 1.5 nM, >450-fold vs thyroid peroxidase in vitro. |
