| Cat. No. |
Product Name |
Information |
| PC-21265 |
Feeblin
IRF5 inhibitor
|
Feeblin (IRF5 inhibitor C5) is a small molecule inhibitor of the proinflammatory TLR7/8/9-IRF5 pathway (IC50=1.6 uM) by disrupting the SLC15A4-TASL adapter module, Feeblin is an IRF5 pathway-specific inhibitor. |
| PC-21260 |
ABR-238901
S100A9 inhibitor
|
ABR-238901 is an orally active and potent S100A9 blocker, inhibits the interaction of S100A9 with its receptors RAGE (receptor for advanced glycation endproducts) and TLR4. |
| PC-21246 |
HAMNO
RPA inhibitor
|
HAMNO (NSC 111847) is a small molecule protein interaction inhibitor of replication protein A (RPA), specifically inhibits RPA DNA binding domain F (DBD-F), inhibits dsDNA unwinding with IC50 of 9 uM. |
| PC-21240 |
NOX-6-7
GPR132 agonist
|
NOX-6-7 is a potent, selective GPR132 agonist with EC50 of 44 nM. |
| PC-21239 |
NOX-6-18
GPR132 inhibitor
|
NOX-6-18 is a potent, selective GPR132 antagonist with IC50 of 17 nM. |
| PC-21231 |
Glutamate-cysteine ligase inhibitor EN25
Glutamate-cysteine ligase inhibitor
|
Glutamate-cysteine ligase inhibitor EN25 is a covalent inhibitor of the glutamate-cysteine ligase (GCL) with IC50 of 16 uM, targets an allosteric cysteine C114 on GCLM, the modifier subunit of GCL. |
| PC-21214 |
GPR61 inverse agonist compound 1
GPR61 inverse agonist
|
GPR61 inverse agonist compound 1 is a potent and selective GPR61 inverse agonist with functional IC50 of 10-11 nM in cAMP assays. |
| PC-21213 |
YL-365
GPR34 inhibitor
|
YL-365 (YL365) is a highly potent, selective and competitive antagonist of GPR34. |
| PC-21207 |
Ticlopidine
CD39 inhibitor
|
Ticlopidine (PCR 5332) is an allosteric, noncompetitive inhibitor of CD39 with the IC50 of 81.7 μM, shows antithrombotic effect. |
| PC-21184 |
UGT8 inhibitor 19
UGT8 inhibitor
|
UGT8 inhibitor 19 (UGT8-IN-1) is a highly potent, selective and orally active ceramide galactosyltransferase enzyme UGT8 inhibitor with IC50 of 0.2 nM. |
| PC-21174 |
Kisspeptin 234
GPR54 inhibitor
|
Kisspeptin 234 (Peptide 234, P234) is a potent kisspeptin receptor (KISS1, GPR54) antagonist antagonist with binding IC50 of 2.7 nM in competition with 125I-kisspeptin-10, blocks the stimulatory effects of kisspeptin on hypothalamus-pituitary-gonadal (HPG) axis. |
| PC-21150 |
ST2 inhibitor XY52
ST2 inhibitor
|
ST2 inhibitor XY52 is a specific small molecule inhibitor of soluble suppression of tumorigenesis-2 factor (ST2) with IC5 of 5.68 and 4.59 uM in ST2/IL-33 AlphaLISA and HEK-Blue reporter assays, repsectively. |
