| Cat. No. |
Product Name |
Information |
| PC-42281 |
GGTI298
GGTase I inhibitor
|
GGTI298 (GGTI-298) is a CAAZ peptidomimetic geranylgeranyltransferase I (GGTase I) inhibitor that inhibits the processing of geranylgeranylated Rap1A with little effect on processing of farnesylated Ha-Ras (IC50s are 3 and >10 uM respectively). |
| PC-27780 |
A8535
GPR27 agonist
|
A8535 is a selective small-molecule GPR27 (SREB1) agonist. |
| PC-27779 |
Phoenixin-14
GPR173 ligand
|
Phoenixin-14 (PNX-14) is an endogenous neuropeptide with multiple biological activities and endogenous ligand of GPR173. |
| PC-27778 |
Phoenixin-20
Neuropeptide
|
Phoenixin-20 (PNX-20) is a bioactive peptide with hormone-like actions in vertebrates, stimulates hypothalamo-pituitary-gonadal hormones and regulates reproductive processes in mammals, promotes neuronal mitochondrial biogenesis via CREB-PGC-1α pathway. |
| PC-27766 |
PI5P4Kγ inhibitor n40
PI5P4Kγ inhibitor
|
PI5P4Kγ inhibitor n40 is a potent, selective orthosteric-allosteric dual inhibitor of PI5P4Kγ with Kd of 6.55 nM, has >1000-fold selectivity over PI5P4Kα and PI5P4Kβ. |
| PC-27764 |
IMYX-3
RAB27 inhibitor
|
IMYX-3 is a first-in-class small molecule oral inhibitor of RAB27, inhibits PMA-activated human neutrophil ROS with IC50 of 0.36 uM in human neutrophils, reduces neutrophil-mediated damage by decreasing ROS, degranulation, and NET formation. |
| PC-27758 |
PI5P4Kγ-IN-1
PI5P4Kγ inhibitor
|
PI5P4Kγ-IN-1 is a potent, selective and ATP-competitive chemical probe inhibitor for PI5P4Kγ with Kd of 19 nM and IC50 of 67 nM, effectively inhibits PI5P4Kγ function and activates the mTORC1 signaling pathway in cells. |
| PC-27757 |
SLK/STK10-IN-1
SLK/STK10 inhibitor
|
SLK/STK10-IN-1 is a potent, selective dual inhibitor of SLK (STE20-like kinase) and STK10 (serine/threonine kinase 10) with IC50 of 1 uM for both in NanoBRET assays in HEK293 cells, shows good kinome-wide selectivity. |
| PC-27755 |
Saikosaponin D
CAS 20874-52-6
|
Saikosaponin D is an active component isolated from Bupleurum falcatum, inhibits activated T lymphocyte proliferation by downregulating the NF-κB, NF-AT, and AP-1 signaling pathways, suppresses enterovirus A71 infection (EV-A71) by inhibiting autophagy, also potently inhibits the proliferation and invasion of cancer cells, induces the apoptosis of cancer cells, and suppresses angiogenesis. |
| PC-27734 |
YS-01
Pendrin inhibitor
|
YS-01 is a potent, specific small molecule inhibitor of Cl-/HCO3- exchanger Pendrin (SLC26A4), potently inhibits pendrin-mediated Cl-/SCN-, Cl-/I-, Cl-/HCO3-, and Cl-/OH- exchange activity in a dose-dependent manner. |
| PC-27733 |
PDSinh-A01
Pendrin inhibitor
|
PDSinh-A01 is a specific small molecule inhibitor of Cl-/HCO3- exchanger Pendrin (SLC26A4) with IC50 of 6.6 uM. |
| PC-27732 |
PDSinh-C01
Pendrin inhibitor
|
PDSinh-C01 is a specific small molecule inhibitor of Cl-/HCO3- exchanger Pendrin (SLC26A4), inhibits Cl−/anion exchange mediated by mouse pendrin with IC50 of 1-3 uM, without affecting other major kidney tubule transporters. |
