| Cat. No. |
Product Name |
Information |
| PC-22448 |
CMFT
MIF inhibitor
|
CMFT is a a small molecule inhibitor of the functional interaction between the transcription factor ICBP90 (a.k.a. UHRF1) and the MIF-794 CATT5-8 promoter microsatellite, inhibits MIF mRNA expression in a -794 CATT5-8 length-dependent manner with an IC50 of 470 nM. |
| PC-22443 |
P4B
Cellulose biosynthesis inhibitor
|
P4B is a small molecule cellulose biosynthesis inhibitor of Arabidopsis (Arabidopsis thaliana) seedling growth. |
| PC-22442 |
UCM-13369
NPM1 inhibitor
|
UCM-13369 is a small molecule inhibitor of nucleophosmin 1 (NPM1), inhibits NPM1 expression, downregulates the pathway associated with mutant NPM1 C+, inhibits tumorsphere growth of CSCs. |
| PC-22430 |
LW-216
TrxR1 inhibitor
|
LW-216 is a novel specific small molecule thioredoxin reductase 1 (TrxR1, TXNRD1) inhibitor directly binds TrxR1 (KD of 8.8 uM in MST assays) and persistently promotes TrxR1 ubiquitination, inhibits TrxR1 expression. |
| PC-22416 |
UCF-101
Omi/HtrA2 inhibitor
|
UCF-101 is a specific inhibitor for the pro-apoptotic protease Omi/HtrA2 with IC50 of 9.5 uM, displays high selectivity over other serine proteases. |
| PC-22408 |
DUPA
Drug delivery ligand
|
DUPA is a small molecule delivery ligand with specificity for prostate-specific membrane antigen (PSMA), commonly used for selectively delivery cytotoxic agents to prostate cancer cells. |
| PC-22397 |
UNC9750
IPMK inhibitor
|
UNC9750 is a potent selective inhibitor of inositol phosphate multikinase (IPMK) with IC50 of 31.6 nM, inhibits human glioblastoma cell growth and selectively decreases cellular InsP5 abundance. |
| PC-22384 |
ML281
STK33 inhibitor
|
ML281 is a potent, selective inhibitor of serine/threonine kinase STK33 with IC50 of 14 nM, >500-fold selective over PKA and AurB. |
| PC-22376 |
18:0 PEG2000 PE
|
18:0 PEG2000 PE is a PEG-modified phospholipid conjugate used in liposome formation of sterically stabilized liposomes with low reticuloendothelial system uptake and increased circulation duration to target cells. |
| PC-22368 |
7-alpha-hydroxycholesterol
TCR inhibitor
|
7alpha-hydroxycholesterol (7a-HC) is the 7alpha-hydroxy derivative of cholesterol, is a potent inhibitor of TCR signaling and promotes membrane binding of CD3ε cytoplasmic domain. |
| PC-22367 |
SHP1705
Cryptochrome stabilizer
|
SHP1705 is a small molecule cryptochrome (CRY) modulator and stabilizer, represses the expression of DBP, CRY1, and PER1, reduces glucose intolerance in obese, insulin-resistant mice. |
| PC-22352 |
Rotenone
Complex I inhibitor
|
Rotenone is a mitochondrial electron transport chain complex I inhibitor, induces apoptosis through enhancing mitochondrial reactive oxygen species production. |
