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Chemical Structure : MASTL inhibitor 15
Catalog No.: PC-23350Not For Human Use, Lab Use Only.
MASTL inhibitor 15 is a potent, highly selective inhibitor of microtubule-associated serine/threonine kinase-like (MASTL, Greatwall) with Ki of <0.03 nM, cellular pENSA IC50 of 1.1 nM in MDA-MB-231 cells.
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MASTL inhibitor 15 is a potent, highly selective inhibitor of microtubule-associated serine/threonine kinase-like (MASTL, Greatwall) with Ki of <0.03 nM, cellular pENSA IC50 of 1.1 nM in MDA-MB-231 cells.
MASTL inhibitor 15 exhibits cellular pENSA IC50 of 4.6 nM in the MiaPaca2 cell line.
MASTL inhibitor 15 displays 420-fold selectivity over MAP4K4, and a sentinel kinase for flagging selectivity over other homologous kinases.
MASTL inhibitor 15 (15 and 30 mg/kg QD and 10 and 15 mg/kg BID, oral) exhibits dose-dependent inhibition of MiaPaca2 xenograft growth.
| M.Wt | 403.49 | |
| Formula | C21H25N9 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Gallego RA, et al. J Med Chem. 2024 Nov 5. doi: 10.1021/acs.jmedchem.4c01659.
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