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GQ262

Chemical Structure : GQ262

CAS No.:

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GQ262

Catalog No.: PC-23378Not For Human Use, Lab Use Only.

GQ262 is a small molecule Gαq/11 protein inhibitor with IC50 of <10 uM, inhibits MP41 cell proliferation with IC50 of 5.1 uM.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

GQ262 is a small molecule Gαq/11 protein inhibitor with IC50 of <10 uM, inhibits MP41 cell proliferation with IC50 of 5.1 uM.
GQ262 efficiently blocked UM cell proliferation and migration in vitro. Analysis of the apoptosis-related proteins, extracellular signal-regulated kinase (ERK), and yes-associated protein (YAP).
GQ262 distinctly induced UM cells apoptosis and disrupted the downstream effectors by targeting Gαq/11 directly.
GQ262 showed outstanding antitumor efficacy in vivo with good safety at the testing dose.

Physicochemical Properties

M.Wt 392.59
Formula C25H36N4
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

(S)-8-(cyclohexylmethyl)-7-(((S)-1-methylpyrrolidin-2-yl)methyl)-2-phenyl-5,6,7,8-tetrahydroimidazo[1,2-a]pyrazine

References

1. Ge Y, et al. Acta Pharm Sin B. 2022 Aug;12(8):3326-3340.

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