AK-778-XXMU

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Chemical Structure : AK-778-XXMU

Catalog No.: PC-23308Not For Human Use, Lab Use Only.

AK-778-XXMU is a small molecule inhibitor of protein ID2 (inhibitor of DNA binding 2) with SPR KD value of 129 nM.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

AK-778-XXMU is a small molecule inhibitor of protein ID2 (inhibitor of DNA binding 2) with SPR KD value of 129 nM.
AK-778-XXMU inhibits cell migration and invasion of glioma cell lines, induces apoptosis, and more importantly, slows down the tumor growth.
Serving as an inhibitor of differentiation, protein ID2 (inhibitor of DNA binding 2) plays an important role in neurogenesis, neovascularization and malignant development of gliomas.

Physicochemical Properties

M.Wt	392.84
Formula	C22H17ClN2O3
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	1-[(3-Chlorophenyl)methyl]-1,3-dihydro-3-hydroxy-3-[2-oxo-2-(2-pyridinyl)ethyl]-2H-indol-2-one

References

1. Zhong G, et al. Bioorg Med Chem. 2021 Nov 1;49:116427.

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AK-778-XXMU

Biological Activity

Physicochemical Properties

References

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