GQ127

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Chemical Structure : GQ127

Catalog No.: PC-23377Not For Human Use, Lab Use Only.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

GQ127 is a potent, selective Gαq/11 signaling pathway inhibitor with IC50 of 22.4 uM. GQ127 shows good efficacy and safety in inositol monophosphate (IP1) assay by directly inhibiting Gαq/11 proteins.
GQ127 induces uveal melanoma cells apoptosis and displayed potent antitumor activities in uveal melanoma cells viability, migration, and invasion.
GQ127 (10-30 mg/kg) significantly suppressed UM xenograft growth in mouse model without severe toxicity at the testing dose.

Physicochemical Properties

M.Wt	408.59
Formula	C25H36N4O
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	(2S,3R)-2-amino-1-((S)-8-(cyclohexylmethyl)-2-phenyl-5,6-dihydroimidazo[1,2-a]pyrazin-7(8H)-yl)-3-methylpentan-1-one

References

1. Ge Y, et al. J Med Chem. 2021 Mar 25;64(6):3131-3152.

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GQ127

Biological Activity

Physicochemical Properties

References

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