| Cat. No. |
Product Name |
Information |
| PC-60714 |
PRD125
ACAT2 inhibitor
|
PRD125 is a potent and selective inhibitor of sterol O-acyltransferase 2 (SOAT2, ACAT2) with IC50 of 11.8 nM, >6,000-fold selectivity over ACAT1. |
| PC-60694 |
LX2931
S1P lyase inhibitor
|
LX-2931 (LX2931) is a potent, selective and orally bioavailable S1P lyase (S1PL) inhibitor. |
| PC-60693 |
S1P Lyase inhibitor 31
S1PL inhibitor
|
S1P Lyase inhibitor 31 is a potent, selective and orally bioavailable S1P lyase (S1PL) inhibitor with enzyme IC50 of 44 nM, cell IC50 of 110 nM. |
| PC-60680 |
ES936
NQO1 inhibitor
|
ES936 is a potent, specific mechanism-based human NAD(P)H: quinone oxidoreductase 1 (NQO1) inhibitor that demonstrates efficient inactivation of NQO1 at 100 nM in in cellular systems. |
| PC-60661 |
PD 404182
DDAH1 inhibitor
|
PD 404182 (PD404182, PD-404182) is a heterocyclic iminobenzothiazine derivative with antimicrobial and anti-inflammatory properties, a potent inhibitor of human DDAH1 activity (IC50=9 uM) and elevates cellular ADMA levels. |
| PC-60650 |
Ru360
MCU inhibitor
|
Ru360 is a cell-permeable mitochondrial calcium uptake (MCU) inhibitor that binds to mitochondria with high affinity (Kd=340 pM) and blocks Ca2+ uptake into mitochondria in vitro with IC50 of 184 pM. |
| PC-60649 |
AG311
Necrosis inducer
|
AG311 is a first-in-class antitumor and antimetastatic agent that induces necrosis in breast cancer tumors, inhibits inhibit mitochondria complex I activity and reduces HIF-1α stabilization. |
| PC-60631 |
OX03050
Squalene synthase inhibitor
|
OX03050 is a potent, competitive squalene synthase inhibitor that upregulate the LDLR in mouse and human liver cell lines with EC50 of 26 nM. |
| PC-60594 |
Dihydromunduletone
GPR56 inhibitor
|
Dihydromunduletone is a rotenoid derivative that selectively inhibits GPR56 (IC50=21 uM) and GPR114/ADGRG5, but not GPR110 or Class A GPCRs. |
| PC-60560 |
LQB-118
|
LQB-118 is an orally active pterocarpanquinone that exhibits antitumoral and antileishmanial activity both in vitro and in vivo. |
| PC-60514 |
Fulacimstat
Chymase inhibitor
|
Fulacimstat (BAY 1142524, BAY1142524) is a potent, orally available chymase inhibitor with IC50 of 4 nM and 3 nM for human and hamster chymase enzyme, respectively. |
| PC-70232 |
NAPQI
MIF inhibitor
|
NAPQI (N-Acetylimidoquinone) is a toxic byproduct, iminoquinone metabolite of acetaminophen that covalently binds to the active site of macrophage migration inhibitory factor (MIF). |
