| Cat. No. |
Product Name |
Information |
| PC-26649 |
mtCI modulator C273
Mitochondrial complex I inhibitor/modulator
|
mtCI modulator C273 is a selective, brain-penetrant, orally bioavailable small molecule modulator/ weak inhibitor of mitochondrial complex I (mtCI) with IC50 of 201.5 uM, protects against Aβ toxicity through mtCI modulation. |
| PC-26639 |
Auxinole
Auxin antagonist
|
Auxinole is a potent auxin antagonist of TIR1/AFB receptors, binding TIR1 to block the formation of the TIR1-IAA-Aux/IAA complex and inhibits auxin-responsive gene expression. |
| PC-26624 |
S720-2261
FIBCD1 inhibitor
|
S720-2261 is a small molecule inhibitor of FIBCD1 (Fibrinogen C domain-containing protein 1) with SPR KD of 585 uM. |
| PC-26623 |
CTI-2
PNC inhibitor
|
CTI-2 is a small molecule inhibitor of perinucleolar compartment (PNC), shows potential anti-AML activity against FLT3-ITD mutant AML. |
| PC-26621 |
BCAT2 inhibitor C11
BACT2 inhibitor
|
BCAT2 inhibitor C11 is a potent, selective branched-chain amino acid transaminase 2 (BCAT2) inhibitor with IC50 of 54 nM. |
| PC-26620 |
BCAT2 inhibitor C10
BACT2 inhibitor
|
BCAT2 inhibitor C10 is a potent, selective branched-chain amino acid transaminase 2 (BCAT2) inhibitor with IC50 of 44 nM. |
| PC-26619 |
BCAT2-IN-2
BACT2 inhibitor
|
BCAT2-IN-2 is a potent, selective, in-vivo efficacious BCATm (BCAT2) inhibitor with pIC50 of 7.3, 100-fold selective for BCATm over BCATc. |
| PC-26618 |
BCAT2-IN-1
BACT2 inhibitor
|
BCAT2-IN-1 is a potent, selective, in-vivo efficacious BCATm (BCAT2) inhibitor with pIC50 of 7.3, 100-fold selective for BCATm over BCATc. |
| PC-26617 |
BAY-771
BAY-069 control
|
BAY-771 is a negative control compound of dual BCAT1/2 inhibitor BAY-069. |
| PC-26616 |
BAY-252
BACT1/BACT2 inhibitor
|
BAY-252 is a potent branched-chain amino acid transaminases 1 (BCAT1) and BCAT2 inhibitor with IC50s of 2 μM and 2 μM, respectively. |
| PC-26613 |
ERG240
BCAT1 inhibitor
|
ERG240 (ERG-240) is a potent, selective, orally active branched-chain amino acid aminotransferase 1 (BCAT1) inhibitor, inhibits recombinant BCAT1 with an IC50 of 0.1-1 nM, with no inhibition on BCAT2. |
| PC-26585 |
FUBP1-IN-1
FUBP1 inhibitor
|
FUBP1-IN-1 is a small molecule inhibitor of transcriptional regulator FUSE binding protein 1 (FUBP1), inhibits the binding of FUBP1 to the FUSE sequence with IC50 of 11.0 uM, reduces cell expansion and induces of cell death in hepatocellular carcinoma cells. |
