| Cat. No. |
Product Name |
Information |
| PC-26755 |
ELOVL1-IN-2
ELOVL1 inhibitor
|
ELOVL1-IN-2 is a specific ELOVL1 inhibitor with IC50 of 21 μM, inhibits the condensation step of fatty acid elongation and reduces the synthesis of very long-chain fatty acids, including C26:0 VLCFA. |
| PC-26747 |
HNF4α agonist (Z)-19
HNF4α agonist
|
HNF4α agonist (Z)-19 is a small molecule agonist of hepatocyte nuclear factor 4 alpha (HNF4α) with EC50 of 9.2 uM and SPR KD of 4.6 uM. |
| PC-26745 |
TTBK1/2-IN-1
TTBK1/2 inhibitor
|
TTBK1/2-IN-1 (Compound 3) is a potent tau tubulin kinase 1 and 2 (TTBK1 and TTBK2) inhibitor with IC50 of 816 nM and 384 nM nM for TTBK1 and TTBK2, respectively. |
| PC-26744 |
TTBK1-IN-2
TTBK1 inhibitor
|
TTBK1-IN-2 (Compound 29) is a potent, brain penetrant Tau-Tubulin kinase (TTBK1) inhibitor with IC50 of 0.24 uM, reduces TDP-43 phosphorylation both in vitro and in vivo. |
| PC-26743 |
TTBK inhibitor 13
TTBK inhibitor
|
TTBK inhibitor 13 (TTBK1/2 inhibitor) is a potent and cell active tau tubulin kinase 1 and 2 (TTBK1 and TTBK2) inhibitor with IC50 of 3 nM and 2.8 nM for TTBK1 and TTBK2, respectively. |
| PC-26724 |
MS351
CBX7 inhibitor
|
MS351 (MS-351) is a specific small molecule antagonist of chromobox 7 (CBX7) chromodomain (CBX7ChD) with Kd of approximately 500 uM by NMR titration, disrupts H3K27me3-mediated CBX7 binding to target genes in chromatin. |
| PC-26685 |
Sulfiredoxin inhibitor J14
Sulfiredoxin inhibitor
|
J14 is a potent, reversible sulfiredoxin (Srx) inhibitor with IC50 of 8.1 uM. |
| PC-26683 |
CES1 inhibitor DL-9
CES1 inhibitor
|
CES1 inhibitor DL-9 is a slow-binding allosteric inhibitor of Carboxylesterase 1 (CES1) with IC50 of 45.36 uM, Cys 390 is critical for the inhibition of CES1 by DL-9. |
| PC-26669 |
SBI-0087702
ATF2 translocator
|
SBI-0087702 is a mitochondrial ATF translocator that promotes the mitochondrial localization of ATF2, inhibits colony formation, cell motility, anchorage-independent growth, and promotes the apoptosis of melanoma cells in an ATF2-dependent manner. |
| PC-26664 |
CNS-11D
Alpha-synuclein inhibitor
|
CNS-11D is a small molecule pathological tau tibrils disassembler that disaggregates brain-extracted tau fibrils in vitro and in vivo. |
| PC-26657 |
Gαo-IN-1
Gαo inhibitor
|
Gαo-IN-1 is a specific small-molecule inhibitor of neuronal G protein Gαo (encoded by GNAO1 gene), decreases the GTP binding rate of Gαo. |
| PC-26649 |
mtCI modulator C273
Mitochondrial complex I inhibitor/modulator
|
mtCI modulator C273 is a selective, brain-penetrant, orally bioavailable small molecule modulator/ weak inhibitor of mitochondrial complex I (mtCI) with IC50 of 201.5 uM, protects against Aβ toxicity through mtCI modulation. |
