Catalog No.: PC-23950Not For Human Use, Lab Use Only.
PKRA7 (PKRA83) is a potent polypeptide chemokine PK2 (Bv8, PROK2) antagonist, potently inhibit PK2 receptors with IC50 of 5.0 and 8.2 nM for PKR1 and PKR2, respectively.
PKRA7 (PKRA83) is a potent polypeptide chemokine PK2 (Bv8, PROK2) antagonist, potently inhibit PK2 receptors with IC50 of 5.0 and 8.2 nM for PKR1 and PKR2, respectively. PKRA7 blocks endothelial cell branching, myeloid cell migration, and PK2-induced expression of specific chemokine/chemokine receptors. PKRA7 decreases subcutaneous and intracranial glioblastoma xenograft tumor growth. PKRA7 enhances the efficacy of chemotherapeutic drugs to reduce glioblastoma and pancreatic xenograft tumor growth.
