| Cat. No. |
Product Name |
Information |
| PC-72584 |
SC-919
IP6K inhibitor
|
SC-919 (SC919) is a potent, selective inhibitor of IP6K (Inositol hexakisphosphate kinase) with IC50 of <5.2, <3.8 and 0.65 nM for human IP6K1/2/3, respectively. |
| PC-72580 |
RECTAS
IKAP activator
|
RECTAS is a small molecule splice modulator that corrects aberrant splicing of familial dysautonomia (FD), promotes exon 20 inclusion of IKBKAP pre-mRNA and expression of IKAP. |
| PC-72579 |
SHMT inhibitor SHIN2
SHMT inhibitor
|
SHMT inhibitor SHIN2 ((+) SHIN2) is a potent, selective, mammalian SHMT1/2 inhibitor with antileukemic effect in vivo. |
| PC-72578 |
AGX51
Id poteins inhibitor
|
AGX51 is a small-molecule antagonist of Id helix-loop-helix (HLH) proteins (Id1-4), inhibits the Id1-E47 interaction, leading to ubiquitin-mediated degradation of Ids. |
| PC-72576 |
SAFit1
FKBP51 inhibitor
|
SAFit1 is a potent and highly selective inhibitor of FKBP51 (K506-binding protein 51) with IC50 of 4 nM, >10,000-fold selectivity over FKBP52. |
| PC-72575 |
SAFit2
FKBP51 inhibitor
|
SAFit2 is a potent and highly selective inhibitor of FKBP51 (K506-binding protein 51) with IC50 of 6 nM, >10,000-fold selectivity over FKBP52. |
| PC-72568 |
MBD2 inhibitor APC
MBD2 inhibitor
|
MBD2 inhibitor APC (APC) is a small molecule inhibitor targeting an intrinsically disordered protein region (IDPR) of MBD2 with antimetastatic activity, inhibits DOT-mediated PPI of MBD2, efficiently disrupts MBD2 interaction with p66α with IC50 of 1.03 uM (FRET). |
| PC-72567 |
MBD2 inhibitor ABA
MBD2 inhibitor
|
MBD2 inhibitor ABA (ABA) is a small molecule inhibitor targeting an intrinsically disordered protein region (IDPR) of MBD2 with antimetastatic activity, inhibits DOT-mediated PPI of MBD2, efficiently disrupts MBD2 interaction with p66α with IC50 of 1.4 uM (FRET). |
| PC-72563 |
CC260
PI5P4Kα/β inhibitor
|
CC260 (CC-260) is a potent, selective inhitor of PI5P4Kα/β with Ki of 40/30 nM, respectively. |
| PC-72561 |
GNS561
PPT1 inhibitor
|
GNS561 (Ezurpimtrostat, GNS-561) is a novel lysosomotropic agent and autophagy inhibitor that induces lysosomal cell death, targets palmitoyl-protein thioesterase 1 (PPT1). |
| PC-72555 |
TET inhibitor C35
TET inhibitor
|
TET inhibitor C35 (Phylloflavan, NSC 607319, TET-IN-C35) is a first-in-class, highly potent, cell-permeable pan-TET inhibitor (TET2 IC50=1.2 uM) that specifically targets TET catalytic domain and reduces 5-hydroxymethylcytosine (5hmC) load on the genome. |
| PC-72554 |
PAX inhibitor BG1
Pax-2 inhibitor
|
PAX inhibitor BG1 (PAX-IN-BG1) is a small molecule inhibitor that attenuate Pax-2 transactivation ability with IC50 of 1.5 uM. |
