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ZY-444

Chemical Structure : ZY-444

CAS No.: 1802650-31-2

ZY-444 (ZY444)

Catalog No.: PC-47056Not For Human Use, Lab Use Only.

ZY-444 is a specific metabolic inhibitor of pyruvate carboxylase, a key anaplerotic enzyme of the tricarboxylic acid cycle (TCA cycle), suppresses breast cancer growth and metastasis through inhibiting the Wnt/β‐catenin/Snail signaling pathway.

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Biological Activity

ZY-444 is a specific metabolic inhibitor of pyruvate carboxylase, a key anaplerotic enzyme of the tricarboxylic acid cycle (TCA cycle), suppresses breast cancer growth and metastasis through inhibiting the Wnt/β‐catenin/Snail signaling pathway.
ZY‐444 displayed potent efficacy against cancer proliferation and invasion but much less toxicity to normal cells.
ZY‐444 selectively inhibited invasive breast cancer (BCA) proliferation (IC90=5 uM), migration, and invasion.
ZY‐444 suppressed BCA growth, metastasis, and lung colonization in vivo.
ZY‐444 is an inhibitor of pyruvate carboxylase (PC) by binding to and inhibiting its enzymatic activity without influencing PC expression.
ZY‐444 inhibited the Wnt signaling pathway in MDA‐MB‐231 cells.

Physicochemical Properties

M.Wt 444.597
Formula C26H28N4OS
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

N4-((5-(4-(benzyloxy)phenyl)thiophen-2-yl)methyl)-N2-isobutylpyrimidine-2,4-diamine

References

1. Qingxiang Lin, et al. Adv Sci (Weinh). 2020 Mar 12;7(9):1903483.

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