You are here:Home-Chemical Inhibitors & Agonists-Others-Other Targets-GBT1118
GBT1118

Chemical Structure : GBT1118

CAS No.: 1628799-51-8

GBT1118 (GBT-1118)

Catalog No.: PC-47075Not For Human Use, Lab Use Only.

GBT1118 is a potent, orally bioavailable allosteric modifier of hemoglobin O2 affinity, binds covalently and reversibly via an imine intermediate to the NH2-terminal valine of the Hb α-chain.

Packing Price Stock Quantity
25 mg Get quote
50 mg Get quote
100 mg Get quote

Bulk size, bulk discount!

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    GBT1118 is a potent, orally bioavailable allosteric modifier of hemoglobin O2 affinity, binds covalently and reversibly via an imine intermediate to the NH2-terminal valine of the Hb α-chain.
    GBT1118 increased Hb O2 affinity and decreased the Po2 during hypoxia in awake-instrumented mice.
    GBT1118 significantly attenuated bleomycin-induced lung fibrosis, collagen accumulation, body weight loss, and leukocyte infiltration in a bleomycin-induced mouse model of hypoxemia and fibrosis.
    GBT1118 significantly improved tolerance to hypoxia in sickle cell mice.

    Physicochemical Properties

    M.Wt 340.379
    Formula C19H20N2O4
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20°C 12 Months; 4°C 6 Months
    In Solvent
    -80°C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO

    Chemical Name/SMILES

    Benzaldehyde, 2-hydroxy-6-[[(2S)-1-(3-pyridinylcarbonyl)-2-piperidinyl]methoxy]-

    References

    1. Geng X, et al. Physiol Rep. 2016 Sep;4(17):e12965.

    2. Dufu K, et al. Am J Physiol Heart Circ Physiol. 2017 Aug 1;313(2):H381-H391.

    3. Dufu K, et al. Am J Physiol Heart Circ Physiol. 2021 Aug 1;321(2):H400-H411.

    Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright

    Contact Us sales@probechem.com

    Bulk Inquiry

    * Indicates a Required FieldYour information is safe with us.

    • *Product name:
    • *Applicant name:
    • *Email address:
    • *Organization name:
    • *Requested quantity:
    • *Country:
    • *Additional Information:

    Get Quote

    * Indicates a Required FieldYour information is safe with us.

    • *Product name:
    • *Applicant name:
    • *Email address:
    • *Organization name:
    • *Requested quantity:
    • *Country:
    • Additional Information: