Chemical Structure : GBT1118
Catalog No.: PC-47075Not For Human Use, Lab Use Only.
GBT1118 is a potent, orally bioavailable allosteric modifier of hemoglobin O2 affinity, binds covalently and reversibly via an imine intermediate to the NH2-terminal valine of the Hb α-chain.
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GBT1118 is a potent, orally bioavailable allosteric modifier of hemoglobin O2 affinity, binds covalently and reversibly via an imine intermediate to the NH2-terminal valine of the Hb α-chain.
GBT1118 increased Hb O2 affinity and decreased the Po2 during hypoxia in awake-instrumented mice.
GBT1118 significantly attenuated bleomycin-induced lung fibrosis, collagen accumulation, body weight loss, and leukocyte infiltration in a bleomycin-induced mouse model of hypoxemia and fibrosis.
GBT1118 significantly improved tolerance to hypoxia in sickle cell mice.
M.Wt | 340.379 | |
Formula | C19H20N2O4 | |
Appearance | Solid | |
Storage |
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Solubility |
10 mM in DMSO |
1. Geng X, et al. Physiol Rep. 2016 Sep;4(17):e12965.
2. Dufu K, et al. Am J Physiol Heart Circ Physiol. 2017 Aug 1;313(2):H381-H391.
3. Dufu K, et al. Am J Physiol Heart Circ Physiol. 2021 Aug 1;321(2):H400-H411.
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