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cjoc42

Chemical Structure : cjoc42

CAS No.: 2171519-89-2

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cjoc42 (cjoc 42)

Catalog No.: PC-47073Not For Human Use, Lab Use Only.

cjoc42 is a specific small molecule that is capable of binding to gankyrin (ITC Kd=580 nM), inhibit gankyrin activity in a dose-dependent manner.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

cjoc42 is a specific small molecule that is capable of binding to gankyrin (ITC Kd=580 nM), inhibit gankyrin activity in a dose-dependent manner.
cjoc42 prevents the decrease in p53 protein levels normally associated with high amounts of gankyrin, and restores p53-dependent transcription and sensitivity to DNA damage.

Physicochemical Properties

M.Wt 415.464
Formula C20H21N3O5S
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

Methyl 4-(4-(3-(tosyloxy)propyl)-1H-1,2,3-triazol-1-yl)benzoate

References

1. Anasuya Chattopadhyay, et al. Sci Rep. 2016 Apr 5;6:23732.

2. D'Souza AM, et al. Front Pharmacol. 2021 Mar 4;12:580722.

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