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Carmofur

Chemical Structure : Carmofur

CAS No.: 61422-45-5

Carmofur (HCFU)

Catalog No.: PC-47071Not For Human Use, Lab Use Only.

Carmofur (HCFU) is a pyrimidine analogue with antineoplastic activity, Carmofur is a highly potent acid ceramidase (ASAH1) inhibitor with IC50 of 29 nM (rat recombinant ASAH1).

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Biological Activity

Carmofur (HCFU) is a pyrimidine analogue with antineoplastic activity, Carmofur is a highly potent acid ceramidase (ASAH1) inhibitor with IC50 of 29 nM (rat recombinant ASAH1).
Carmofur inhibits acid ceramidase (ASAH1) activity and elevates tissue ceramide levels, both in vitro and in vivo.
Carmofur act synergistically with standard antitumoral drugs to prevent cancer cell proliferation.
Carmofur is highly effective and specifically target glioblastoma GSCs.

Physicochemical Properties

M.Wt 257.26
Formula C11H16FN3O3
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
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Solubility

10 mM in DMSO

Chemical Name/SMILES

5-fluoro-N-hexyl-2,4-dioxopyrimidine-1-carboxamide

References

1. Doan NB, et al. Oncol Rep. 2017 Oct;38(4):1932-1940.

2. Natalia Realini, et al. Sci Rep. 2013;3:1035. doi: 10.1038/srep01035.

3. Doan NB, et al. Oncotarget. 2017 Nov 7;8(68):112662-112674.

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