| Cat. No. |
Product Name |
Information |
| PC-20718 |
BPN-14136
RBP4 inhibitor
|
BPN-14136 is a potent, selective and non-retinoid RBP4 antagonist with SPA IC50 of 12.8 nM and HTRF IC50 of 43.6 nM. |
| PC-20714 |
ME-143
NADH oxidase inhibitor
|
ME-143 (NV-143) is a second-generation tumor-specific NADH oxidase inhibitor, binds to purified recombinant ENOX2 with Kd value of 43 nM, shows broad activity against human cancers in vitro and in vivo. |
| PC-20699 |
TXX-1-10
HPIP inhibitor
|
TXX-1-10 (CB1-8) is a small chemical molecule that inhibits HPIP oncoprotein expression, suppresses breast cancer cell growth and metastasis in vitro and in vivo. |
| PC-20609 |
SN34960
Perforin inhibitor
|
SN34960 is a small molecule Perforin inhibitor, inhibits perforin-induced lysis of Jurkat T-lymphoma cells with IC50 of 6.65 uM, shows suboptimal physicochemical properties and toxicity toward the natural killer (NK) cells that secrete perforin in vivo. |
| PC-20604 |
Auranofin
TrxR inhibitor, UBA1 enhancer
|
Auranofin (SKF39162) is a specific inhibitor of thioredoxin reductase (TrxR), also is a potent UBA1 E1 ubiquitin-activating enzyme activity enhancer. |
| PC-20580 |
RX-207
SMIGs inhibitor
|
RX-207 (RX207) is a small molecule inhibitor of protein binding to glycosaminoglycans (SMIGs), inhibits protein binding to glycosaminoglycans (GAGs), inhibits inflammatory neutrophil adhesion and activity in vitro and in vivo. |
| PC-20567 |
PF-04859989
Kynurenine aminotransferase II inhibitor
|
PF-04859989 is a potent, selective, brain-penetrant, irreversible inhibitor of human and rat KAT II (kynurenine aminotransferase II) with IC50 of 23 and 263 nM, respectively. |
| PC-20557 |
GKI-1
MASTL inhibitor
|
GKI-1 (Greatwall Kinase Inhibitor-1) is a specific small-molecule inhibitor of MASTL (microtubule-associated serine/threonine kinase-like, Greatwall/GWL) with IC50 of 10.2 uM. |
| PC-20555 |
MKI-1
MASTL inhibitor
|
MKI-1 (MASTL inhibitor 1) is a small molecule MASTL (microtubule-associated serine/threonine kinase-like, Greatwall/GWL) inhibitor with IC50 of 9.9 uM. |
| PC-20554 |
YQ456
Myoferlin inhibitor
|
YQ456 (YQ-456) is a specific small molecule inhibitor of Myoferlin (MYOF) with high binding affinity (KD=37 nM) to MYOF‐C2D domain, suppresses colorectal cancer invasion in vitro with IC50 of 110 nM. |
| PC-20553 |
Igf2bp1 inhibitor 7773
Igf2bp1 inhibitor
|
Igf2bp1 inhibitor 7773 is a specific small molecule inhibitor of Igf2bp1, binds to RNA binding domains of Igf2bp1, inhibits Igf2bp1 binding of Kras 6 RNA with IC50 of 30 uM. |
| PC-20507 |
SRC-3 inhibitor SI-12
SRC-3 inhibitor
|
SRC-3 inhibitor SI-12 is a potent small molecule inhibitor of steroid receptor coactivator (SRC-3), inhibits MCF-7 breast cancer cell growth with IC50 of 7 nM, exhibits low hERG activity (IC50=1.13 uM). |
