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Cat. No. Product Name Information
PC-49754

MM0299

Lanosterol synthase inhibitor

MM0299 (MM 0299) is a potent, selective inhibitor of lanosterol synthase (LSS, competition EC50=1.97 nM) with anti-proliferative activity, inhibits Mut6 cell growth (IC50=18.2 nM) and induces the synthesis of 24(S),25-epoxycholesterol (EPC).
PC-49750

DDAH1 inhibitor 8

DDAH1 inhibitor

DDAH1 inhibitor 8 is a potent, selective, nonamino acid, catalytic site inhibitor of human dimethylarginine dimethylaminohydrolase-1 (hDDAH-1) with Ki of 18 uM, with no significantly affecting NOSs and arginase.
PC-49743

M50054

Apoptosis inhibitor

M50054 (M 50054) is a small molecule inhibitor of apoptosis (programmed cell death), inhibits soluble human Fas ligand-induced cell death of human Fasexpressing WC8 cells with IC50 of 67 ug/mL.
PC-49739

MS0621

EWSR1::FLI1 modulator

MS0621 (UNC0621, MS 0621) is a small-molecule modulator of EWSR1::FLI1-mediated chromatin, reverses EWSR1::FLI1-mediated chromatin accessibility, persistently and selectively inhibits cell proliferation in Ewing sarcoma cell lines (SK-N-MC, IC50=128 nM).
PC-49735

Lixumistat

OXPHOS inhibitor

IM156 (Lixumistat, HL156A, IM-156) is a metformin derivative and potent biguanide OXPHOS inhibitor of Protein Complex 1 (PC1) of the mitochondrial electron transport chain, also shows higher potency of AMPK activation than metformin.
PC-49731

trans-MiM111

Mitofusin activator

trans-MiM111 is a small molecule short acting mitofusin activator, increases mitochondrial motility in MFN2 T105M expressing mouse DRGs with EC50 of 3.6 nM (Emax=93).
PC-49730

CPR1-B

Mitofusin activator

CPR1-B is a longer-acting phenylhexanamide mitofusin activator, increases mitochondrial motility in MFN2 T105M expressing mouse DRGs with EC50 of 3.3 nM (Emax=89%).
PC-49721

SBT-272

Cardiolipin stablizer

SBT-272 (Bevemipretide) is a brain-penetrant small molecule that stabilizes cardiolipin, a phospholipid found in inner mitochondrial membrane (IMM), thereby restoring mitochondrial structure and respiratory function.
PC-49719

EPI-589

Oxidoreductase inhibitor

EPI-589 (EPI 589) is an orally available, blood-brain barrier permeable redox-active agent characterized by highly potent protective effects against oxidative stress, attenuates oxidative stress due to the radical scavenging activity of the reduced form and affects mitochondrial energy metabolism as a substrate of quinone-oxidoreductases.
PC-49704

NUP-17d-52A

Plek2 inhibitor

NUP-17d-52A (Plek2 inhibitor) is a specific small molecule inhibitor of Pleckstrin-2 (Plek2), binds to Plek2-DEP domain with high affinity (Kd=160 nM).
PC-49703

Plek2 inhibitor NUP-17d

Plek2 inhibitor

Plek2 inhibitor NUP-17d is a specific small molecule inhibitor of Pleckstrin-2 (Plek2), binds to Plek2 and Plek2-DEP with high affinity (ITC KD=109 and 350 nM, respectively).
PC-49693

Xist inhibitor X1

Xist inhibitor

Xist inhibitor X1 is a selective small molecule inhibitor of the non-coding RNA prototype Xist function, binds specifically to the RepA motif of Xist (Kd=0.4 uM) in vitro and in vivo.

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