Betulin | SREBP inhibitor | Probechem Biochemicals

Chemical Structure : Betulin

CAS No.: 473-98-3

Betulin (NSC 4644)

Catalog No.: PC-20459Not For Human Use, Lab Use Only.

Betulin (NSC 4644) is a specific small molecule inhibitor of SREBP (Sterol regulatory element-binding protein), specifically inhibits the maturation of SREBP by inducing interaction of SREBP cleavage activating protein (SCAP) and Insig.

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100 mg	$198	In stock
200 mg	$288	In stock
500 mg	$458	In stock
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Biological Activity

Betulin (NSC 4644) is a specific small molecule inhibitor of SREBP (Sterol regulatory element-binding protein), specifically inhibits the maturation of SREBP by inducing interaction of SREBP cleavage activating protein (SCAP) and Insig.

Betulin binds to SREBP cleavage activating protein (SCAP), stimulates the interaction between SCAP and Insig, blocks the maturation of SREBPs

Betulin specifically inhibits the SREBP processing but does not activate LXR or accelerate HMGCR degradation.

Betulin downregulates SREBP target genes and decreases cellular lipid levels, including HMGCR, HMG-CoA synthase (HMGCS), and squalene epoxidase (SE), SREBP-1c, fatty acid synthase (FAS), and acetyl-Co A carboxylase alpha (ACC).

Betulin decreased the lipid levels in serum and tissues and increased insulin sensitivity in western-type diet ingested mice.

Betulin reduced the size and improved the stability of atherosclerotic plaques in atherosclerosis disease model, LDLR-knockout mice.

Physicochemical Properties

M.Wt	442.73
Formula	C30H50O2
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(1R,3aS,5aR,5bR,7aR,9S,11aR,11bR,13aR,13bR)-3a-(hydroxymethyl)-5a,5b,8,8,11a-pentamethyl-1-(prop-1-en-2-yl)icosahydro-1H-cyclopenta[a]chrysen-9-ol

References

1. Tang JJ, et al. Cell Metab. 2011 Jan 5;13(1):44-56.

Betulin (NSC 4644)

Biological Activity

Physicochemical Properties

References

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