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Chemical Structure : PF-04859989
CAS No.: 34783-48-7
Catalog No.: PC-20567Not For Human Use, Lab Use Only.
PF-04859989 is a potent, selective, brain-penetrant, irreversible inhibitor of human and rat KAT II (kynurenine aminotransferase II) with IC50 of 23 and 263 nM, respectively.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $98 | In stock | |
| 25 mg | $158 | In stock | |
| 50 mg | $248 | In stock | |
| 100 mg | Get quote |
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PF-04859989 is a potent, selective, brain-penetrant, irreversible inhibitor of human and rat KAT II (kynurenine aminotransferase II) with IC50 of 23 and 263 nM, respectively.
PF-04859989 is selective for KAT II over human KAT I, KAT III, and KAT IV (IC50 values of 22, 11, and >50 μM, respectively).
PF-04859989 is capable of reducing brain kynurenic acid by 50% at a dose of 10 mg/kg (sc).
| M.Wt | 178.19 | |
| Formula | C9H10N2O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
O=C1N(O)C2=C(C=CC=C2)C[C@@H]1N |
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1. Dounay AB, et al. ACS Med Chem Lett. 2012 Jan 25;3(3):187-92.
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