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PF-04859989

Chemical Structure : PF-04859989

CAS No.: 34783-48-7

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PF-04859989 (PF 04859989)

Catalog No.: PC-20567Not For Human Use, Lab Use Only.

PF-04859989 is a potent, selective, brain-penetrant, irreversible inhibitor of human and rat KAT II (kynurenine aminotransferase II) with IC50 of 23 and 263 nM, respectively.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

PF-04859989 is a potent, selective, brain-penetrant, irreversible inhibitor of human and rat KAT II (kynurenine aminotransferase II) with IC50 of 23 and 263 nM, respectively.
PF-04859989 is selective for KAT II over human KAT I, KAT III, and KAT IV (IC50 values of 22, 11, and >50 μM, respectively).
PF-04859989 is capable of reducing brain kynurenic acid by 50% at a dose of 10 mg/kg (sc).

Physicochemical Properties

M.Wt 178.19
Formula C9H10N2O2
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

O=C1N(O)C2=C(C=CC=C2)C[C@@H]1N

References

1. Dounay AB, et al. ACS Med Chem Lett. 2012 Jan 25;3(3):187-92.

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