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OSM-SMI-10B

Chemical Structure : OSM-SMI-10B

CAS No.: 2502294-55-3

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OSM-SMI-10B (SMI-10B)

Catalog No.: PC-20489Not For Human Use, Lab Use Only.

OSM-SMI-10B (SMI-10B) is a first-in-class small molecule inhibitor binds to oncostatin M (OSM) with Kd of 13.6 uM, significantly reduces OSM-induced STAT3 phosphorylation in cancer cells.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    OSM-SMI-10B (SMI-10B) is a first-in-class small molecule inhibitor binds to oncostatin M (OSM) with Kd of 13.6 uM, significantly reduces OSM-induced STAT3 phosphorylation in cancer cells.

    Physicochemical Properties

    M.Wt 378.34
    Formula C21H14O7
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20°C 12 Months; 4°C 6 Months
    In Solvent
    -80°C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    (E)-3-(4,5-bis(benzo[d][1,3]dioxol-5-yl)furan-2-yl)acrylic acid

    References

    1. Olga A Mass, et al. Sci Rep. 2021 Aug 10;11(1):16174.

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