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MKI-1

Chemical Structure : MKI-1

CAS No.: 1190277-80-5

MKI-1 (MASTL inhibitor 1)

Catalog No.: PC-20555Not For Human Use, Lab Use Only.

MKI-1 (MASTL inhibitor 1) is a small molecule MASTL (microtubule-associated serine/threonine kinase-like, Greatwall/GWL) inhibitor with IC50 of 9.9 uM.

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Biological Activity

MKI-1 (MASTL inhibitor 1) is a small molecule MASTL (microtubule-associated serine/threonine kinase-like, Greatwall/GWL) inhibitor with IC50 of 9.9 uM.
MKI-1 (15 μM, 20h) inhibited the phosphorylation of ENSA in MCF7 and T47D cells, also inhibited the phosphorylation of ENSA in colcemid-induced mitotic MCF7 cells, did not modulate phosphorylated AKT, GSK-3β, and p70S6K.
MKI-1 inhibits various oncogenic properties of MCF7 cells and does not affect the viability of MCF10A cells.
MKI-1 reduces tumor growth and radiosensitivity of breast cancer cells.
MKI-1 reduces c-Myc stability through PP2A activation in MCF7 cells, inhibits meiotic resumption and spindle formation in mouse oocytes.

Physicochemical Properties

M.Wt 302.34
Formula C18H14N4O
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

N-(1H-benzo[d]imidazol-2-yl)-3-(1H-pyrrol-1-yl)benzamide

References

1. Kim AY, et al. Front Oncol. 2020 Sep 29;10:571601.

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