Chemical Structure : MKI-1
CAS No.: 1190277-80-5
Catalog No.: PC-20555Not For Human Use, Lab Use Only.
MKI-1 (MASTL inhibitor 1) is a small molecule MASTL (microtubule-associated serine/threonine kinase-like, Greatwall/GWL) inhibitor with IC50 of 9.9 uM.
Packing | Price | Stock | Quantity |
---|---|---|---|
5 mg | $198 | In stock | |
10 mg | $298 | In stock | |
25 mg | $488 | In stock | |
50 mg | Get quote | ||
100 mg | Get quote |
Bulk size, bulk discount!
E-mail: sales@probechem.com
Tech Support: tech@probechem.com
MKI-1 (MASTL inhibitor 1) is a small molecule MASTL (microtubule-associated serine/threonine kinase-like, Greatwall/GWL) inhibitor with IC50 of 9.9 uM.
MKI-1 (15 μM, 20h) inhibited the phosphorylation of ENSA in MCF7 and T47D cells, also inhibited the phosphorylation of ENSA in colcemid-induced mitotic MCF7 cells, did not modulate phosphorylated AKT, GSK-3β, and p70S6K.
MKI-1 inhibits various oncogenic properties of MCF7 cells and does not affect the viability of MCF10A cells.
MKI-1 reduces tumor growth and radiosensitivity of breast cancer cells.
MKI-1 reduces c-Myc stability through PP2A activation in MCF7 cells, inhibits meiotic resumption and spindle formation in mouse oocytes.
M.Wt | 302.34 | |
Formula | C18H14N4O | |
Appearance | Solid | |
Storage |
|
|
Solubility |
10 mM in DMSO |
|
Chemical Name/SMILES |
N-(1H-benzo[d]imidazol-2-yl)-3-(1H-pyrrol-1-yl)benzamide |
1. Kim AY, et al. Front Oncol. 2020 Sep 29;10:571601.
Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright