Catalog No.: PC-20507Not For Human Use, Lab Use Only.
SRC-3 inhibitor SI-12 is a potent small molecule inhibitor of steroid receptor coactivator (SRC-3), inhibits MCF-7 breast cancer cell growth with IC50 of 7 nM, exhibits low hERG activity (IC50=1.13 uM).
SRC-3 inhibitor SI-12 is a potent small molecule inhibitor of steroid receptor coactivator (SRC-3), inhibits MCF-7 breast cancer cell growth with IC50 of 7 nM, exhibits low hERG activity (IC50=1.13 uM).
SRC-3 inhibitor SI-12 (5–50 nM) can significantly inhibit viability, migration and invasion of breast cancer cells in vitro and repress the growth of breast cancer PDX organoids.
SRC-3 inhibitor SI-12 (10 mg/kg/day) was sufficient to repress growth of xenograft tumors derived from MDA-MB-231 and LM2 cells.
SRC-3 inhibitor SI-12 effectively inhibited progression of breast cancer lung metastasis in spontaneous and experimental metastasis mouse models developed from MDA-MB-231 and LM2 cells respectively.
Physicochemical Properties
M.Wt
319.29
Formula
C15H12F3N5
Appearance
Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility
10 mM in DMSO
Chemical Name/SMILES
CN1C(N/N=C(C2=NC=C(F)C=C2)\C)=NC3=CC(F)=C(F)C=C13
References
1. Li Qin, et al. Endocr Relat Cancer. 2021 Aug 13;28(10):657-670.
