Catalog No.: PC-20506Not For Human Use, Lab Use Only.
SRC-3 inhibitor SI-10 is a potent small molecule inhibitor of steroid receptor coactivator (SRC-3), inhibits MCF-7 breast cancer cell growth with IC50 of 8.5 nM, exhibits low hERG activity (IC50>10 uM).
SRC-3 inhibitor SI-10 is a potent small molecule inhibitor of steroid receptor coactivator (SRC-3), inhibits MCF-7 breast cancer cell growth with IC50 of 8.5 nM, exhibits low hERG activity (IC50>10 uM).
SRC-3 inhibitor SI-10 (5–50 nM) can significantly inhibit viability, migration and invasion of breast cancer cells in vitro and repress the growth of breast cancer PDX organoids.
SRC-3 inhibitor SI-10 (10 mg/kg/day) was sufficient to repress growth of xenograft tumors derived from MDA-MB-231 and LM2 cells.
SRC-3 inhibitor SI-10 effectively inhibited progression of breast cancer lung metastasis in spontaneous and experimental metastasis mouse models developed from MDA-MB-231 and LM2 cells respectively.
Physicochemical Properties
M.Wt
302.29
Formula
C14H12F2N6
Appearance
Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility
10 mM in DMSO
Chemical Name/SMILES
C/C(C1=NC=CC=N1)=N\N=C2N(C)C3=CC(F)=C(F)C=C3N\2
References
1. Li Qin, et al. Endocr Relat Cancer. 2021 Aug 13;28(10):657-670.
