You are here:Home-Chemical Inhibitors & Agonists-Others-Other Targets-SRC-3 inhibitor SI-10
SRC-3 inhibitor SI-10

Chemical Structure : SRC-3 inhibitor SI-10

CAS No.: 2137490-93-6

SRC-3 inhibitor SI-10

Catalog No.: PC-20506Not For Human Use, Lab Use Only.

SRC-3 inhibitor SI-10 is a potent small molecule inhibitor of steroid receptor coactivator (SRC-3), inhibits MCF-7 breast cancer cell growth with IC50 of 8.5 nM, exhibits low hERG activity (IC50>10 uM).

Packing Price Stock Quantity
50 mg Get quote
100 mg Get quote
200 mg Get quote

Bulk size, bulk discount!

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    SRC-3 inhibitor SI-10 is a potent small molecule inhibitor of steroid receptor coactivator (SRC-3), inhibits MCF-7 breast cancer cell growth with IC50 of 8.5 nM, exhibits low hERG activity (IC50>10 uM).
    SRC-3 inhibitor SI-10 (5–50 nM) can significantly inhibit viability, migration and invasion of breast cancer cells in vitro and repress the growth of breast cancer PDX organoids.
    SRC-3 inhibitor SI-10 (10 mg/kg/day) was sufficient to repress growth of xenograft tumors derived from MDA-MB-231 and LM2 cells.
    SRC-3 inhibitor SI-10 effectively inhibited progression of breast cancer lung metastasis in spontaneous and experimental metastasis mouse models developed from MDA-MB-231 and LM2 cells respectively.

    Physicochemical Properties

    M.Wt 302.29
    Formula C14H12F2N6
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20°C 12 Months; 4°C 6 Months
    In Solvent
    -80°C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO

    Chemical Name/SMILES

    C/C(C1=NC=CC=N1)=N\N=C2N(C)C3=CC(F)=C(F)C=C3N\2

    References

    1. Li Qin, et al. Endocr Relat Cancer. 2021 Aug 13;28(10):657-670.

    Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright

    Contact Us sales@probechem.com

    Bulk Inquiry

    * Indicates a Required FieldYour information is safe with us.

    • *Product name:
    • *Applicant name:
    • *Email address:
    • *Organization name:
    • *Requested quantity:
    • *Country:
    • *Additional Information:

    Get Quote

    * Indicates a Required FieldYour information is safe with us.

    • *Product name:
    • *Applicant name:
    • *Email address:
    • *Organization name:
    • *Requested quantity:
    • *Country:
    • Additional Information: