| Cat. No. |
Product Name |
Information |
| PC-49562 |
F12511
ACAT inhibitor
|
Eflucimibe (F 12511) is a highly potent, selective inhibitor of acyl-CoA: cholesterol acyltransferase ( ACAT/SOAT) with IC50 of 3, 7, and 71 nM in whole cell assays using HepG2, CaCo-2 and THP-1 cell lines, respectively. |
| PC-49561 |
NTE-122
ACAT inhibitor
|
NTE-122 (NTE122) is a potent selective and competitive acyl-CoA:cholesterol acyltransferase (ACAT) inhibitor, inhibits microsomal ACAT activities of various tissues and cultured cells (HepG2 and CaCo-2), with IC50 values from 1.2 to 9.6 nM. |
| PC-49557 |
FR054
PGM3 inhibitor
|
FR054 (FR-054) is a specific small molecule inhibitor of hexosamine biosynthetic pathway (HBP) enzyme N-Acetylglucosamine-phosphate Mutase (PGM3), shows a remarkable anti-breast cancer effect. |
| PC-49527 |
SEN177
Gutaminyl cyclase inhibitor
|
SEN177 (SEN-177) is a highly potent human glutaminyl cyclase (hQC) inhibitor Ki value of 20 nM. |
| PC-49516 |
LCRF-0004
Ron kinase inhibitor
|
LCRF-0004 is a potent and selective RON receptor tyrosine kinase inhibitor with IC50 of 50 nM (ELISA), weakly inhibits c-Met with IC50 of 150 nM and does not inhibit VEGFR2. |
| PC-49511 |
Tryptolinamide
PFK1 inhibitor
|
Tryptolinamide (TLAM) is a small-molecule compound that activates mitochondrial respiration in cybrids generated from patient-derived mitochondria and fibroblasts from patient-derived iPSCs, inhibits phosphofructokinase-1 (PFK1) with an ATP-uncompetitive and F6P-competitive manner (Ki=5.0 uM). |
| PC-49471 |
MO-I-1100
ASPH inhibitor
|
MO-I-1100 is a small molecule inhibitor of aspartyl-(asparaginyl)-β-hydroxylase (ASPH), inhibits the β-hydroxylase activity of ASPH about 80%, inhibits Notch signaling in HCC cancer cells. |
| PC-49459 |
TH301
CRY2 stabilizer
|
TH301 (TH 301) is a selective small molecule stabilizer of Cryptochrome 2 (CRY2).
KL101 showed selectivity over CRY1, and no or only minor effects on CKIδ, CKIα and CK2 activities in vitro. |
| PC-49458 |
KL101
CRY1 stabilizer
|
KL101 (KL 101) is a isoform-selective small molecule stabilizer of Cryptochrome 1 (CRY1). |
| PC-49457 |
PGP inhibitor CP1
PGP inhibitor
|
PGP inhibitor CP1 is a specific small-molecule phosphoglycolate phosphatase (PGP) inhibitor with IC50 of 0.39 uM (hPGP), blocks PGP-dependent glycolytic flux in mammalian cells. |
| PC-49456 |
CRY1 destabilizer M47
CRY1 destabilizer
|
CRY1 destabilizer M47 is a selective small molecule that destabilizes Cryptochrome 1 (CRY1) both in vitro and in vivo, binds to the primary pocket in the PHR domain and specifically destabilizes CRY1 by enhancing its ubiquitination. |
| PC-49448 |
Eliglustat
GCS inhibitor
|
Eliglustat (GENZ 112638)Eliglustat (GENZ 112638) is a ceramide analog and an orally bioavailable inhibitor of glucosylceramide synthase (GCS, ceramide glucosyltransferase) with IC50 of 20 nM in free-cell assays. |
