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Cat. No. Product Name Information
PC-73021

nTRD22

TDP-43-RNA inhibitor

nTRD22 is a small molecule that binds to the TDP-43 N-terminal domain (Kd=143 uM), causes allosteric modulation of the RNA binding domain (RRM) of TDP-43, resulting in decreased binding to RNA in vitro.
PC-73020

rTRD01

TDP-43-RNA inhibitor

rTRD01 is a specific small molecule that binds to TDP-43 RRM1 and RRM2 domains (Kd=89 uM), disrupts TDP-43 interaction with the hexanucleotide RNA repeat of the disease-linked c9orf 72 gene.
PC-73009

SPL-410

SPPL2a inhibitor

SPL-410 (SPL410) is a highly potent, selective, orally active inhibitor SPPL2a (Signal Peptide Peptidase Like 2a) with IC50 of 9 nM.
PC-73006

Pyrcoumin

dCTPP1 inhibitor

Pyrcoumin is a competitive inhibitor of dCTP pyrophosphatase 1 (dCTPP1, IC50=3.3 uM), inhibits Wnt signaling with IC50 of 8.4 uM in SuperTOPFlash reporter gene assays.
PC-72986

BI-9466

BI-9466 (BI 9466) is the negative control of NSD3-PWWP1 domain chemical probe BI-9321.
PC-72977

NFAT-AP-1 interaction inhibitor 10

NFAT inhibitor

NFAT-AP-1 interaction inhibitor 10 (NFAT inhibitor compound 10) is a small-molecule inhibitor nuclear factor of activated T cells (NFAT) with IC50 of 2 uM in FRET assays.
PC-72976

FOXM1 inhibitor RCM-1

FOXM1 inhibitor

FOXM1 inhibitor RCM-1 (Robert Costa Memorial drug-1, RCM-1) is a small molecule potent inhibitor of FOXM1 transcription factor.
PC-72968

SOD3 inducer BNTA

SOD3 inducer

SOD3 inducer BNTA (BNTA) is a small molecule with ECM modulatory properties with target of Superoxide dismutase 3 (SOD3), a strong chondrogenic inducer that increased anabolism of chondrocytes in vitro.
PC-72962

TASIN-1

EBP inhibitor

TASIN-1 (Truncated APC selective inhibitor-1) is a small molecule that specifically kills cells with APC truncations but spares normal and cancer cells with wild-type APC, inhibits emopamil-binding protein (EBP).
PC-72961

CW3388

EBP inhibitor

CW3388 (CW-3388, CW3388) is a potent, cell-active Δ8,7-sterol isomerase (EBP) inhibitor, shows near-maximal effects on oligodendrocyte formation at 110 nM.
PC-72959

Etavopivat

PKR activator

Etavopivat (FT-4202) is a novel oral activator of PKR that decreases 2,3-DPG levels and hence would increase the HbS O2 affinity to reduce sickling.
PC-72948

CMP05-7

Endosomolytic compound

CMP05-7 (Endosomolytic compound CMP05-7) is a novel endosomolytic small-molecule compound that exhibits higher transfection efficiency/ability to induce endosomal escape of oligonucleotides (ONs) than current compounds such as chloroquine.

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