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NCGC607

Chemical Structure : NCGC607

CAS No.: 1462267-07-7

NCGC607 (NCGC00241607)

Catalog No.: PC-38530Not For Human Use, Lab Use Only.

NCGC00241607 (NCGC607) is a small-molecule noninhibitory chaperone of glucocerebrosidase (GCase), successfully chaperoned the mutant enzyme, restored GCase activity and protein levels, and reduced glycolipid storage in neurons.

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Biological Activity

NCGC00241607 (NCGC607) is a small-molecule noninhibitory chaperone of glucocerebrosidase (GCase), successfully chaperoned the mutant enzyme, restored GCase activity and protein levels, and reduced glycolipid storage in neurons.
NCGC607 (3 uM) significantly enhanced GCase activity and increased GCase levels in Gaucher macrophages.
Treatment of Gaucher iDA neurons with NCGC607 increased GCase activity, enhanced translocation of mutant GCase to the lysosome, and reduced substrate levels.
NCGC607 (3 uM) reversed α-Syn accumulation in GD-PD iDA neurons.

Physicochemical Properties

M.Wt 543.3
Formula C24H22IN3O4
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

2-[2-[(4-iodophenyl)amino]-2-oxoethoxy]-N-[2-(methylphenylamino)-2-oxoethyl]-benzamide

References

1. Elma Aflaki, et al. J Neurosci. 2016 Jul 13;36(28):7441-52.

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