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Chemical Structure : ML180
CAS No.: 863588-32-3
Catalog No.: PC-38445Not For Human Use, Lab Use Only.
ML180 (SR1848) is a potent, selective Liver Receptor Homologue-1 (LRH1, NR5A2) inverse agonist with IC50 of 3.7 uM in reporter assays, displays no activity against SF1 (NR5A1).
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $78 | In stock | |
| 10 mg | $118 | In stock | |
| 25 mg | $218 | In stock | |
| 50 mg | $358 | In stock | |
| 100 mg | Get quote |
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ML180 (SR1848) is a potent, selective Liver Receptor Homologue-1 (LRH1, NR5A2) inverse agonist with IC50 of 3.7 uM in reporter assays, displays no activity against SF1 (NR5A1).
ML180 shows 60% maximum repression of LRH1 transcription and is potent in a variety of breast cancer cell lines in MTT assays.
ML180 decreased cell-cycle-related gene transcripts and downstream targets in vitro.
| M.Wt | 388.89 | |
| Formula | C20H25ClN4O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
|
| Chemical Name/SMILES |
6-[4-(3-Chlorophenyl)-1-piperazinyl]-3-cyclohexyl-2,4(1H,3H)-pyrimidinedione |
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1. Busby S, et al. National Center for Biotechnology Information (US); 2010-.
2. Meinsohn MC, et al. J Endocr Soc. 2017 Dec 1;2(1):24-41.
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