Catalog No.: PC-38445Not For Human Use, Lab Use Only.
ML180 (SR1848) is a potent, selective Liver Receptor Homologue-1 (LRH1, NR5A2) inverse agonist with IC50 of 3.7 uM in reporter assays, displays no activity against SF1 (NR5A1).
ML180 (SR1848) is a potent, selective Liver Receptor Homologue-1 (LRH1, NR5A2) inverse agonist with IC50 of 3.7 uM in reporter assays, displays no activity against SF1 (NR5A1).
ML180 shows 60% maximum repression of LRH1 transcription and is potent in a variety of breast cancer cell lines in MTT assays.
ML180 decreased cell-cycle-related gene transcripts and downstream targets in vitro.
