Catalog No.: PC-38444Not For Human Use, Lab Use Only.
ML179 (SR1309) is a potent, selective Liver Receptor Homologue-1 (LRH1, NR5A2) inverse agonist with IC50 of 320 nM in reporter assays, displays no activity against SF1 (NR5A1).
ML179 (SR1309) is a potent, selective Liver Receptor Homologue-1 (LRH1, NR5A2) inverse agonist with IC50 of 320 nM in reporter assays, displays no activity against SF1 (NR5A1).
ML179 is potent in a variety of breast cancer cell lines in MTT assays.
ML179 significantly reduced mRNA expression of FXR targets ATP binding cassette subfamily C member 2/multidrug resistance associated protein 2 (ABCC2/MRP2), nuclear receptor subfamily 0, groupB, member 2/small heterodimer partner (NR0B2/SHP), and ATP binding cassette subfamily B member 11/bile salt export pump (ABCB11/BSEP) in HepG2 cells and primary mouse hepatocytes.
