Catalog No.: PC-38478Not For Human Use, Lab Use Only.
KYP-2047 is a high affinity prolyl oligopeptidase (PREP) inhibitor with Ki of 0.023 nM, reduces α-synuclein protein levels and aggregates in cellular and animal models of PD.
KYP-2047 is a high affinity prolyl oligopeptidase (PREP) inhibitor with Ki of 0.023 nM, reduces α-synuclein protein levels and aggregates in cellular and animal models of PD.
KYP-2047 significantly reduced the number of cells with α-synuclein inclusions while abolishing the colocalization of α-synuclein and PREP.
KYP-2047 significantly reduced the amount of aggregated α-synuclein,and it had beneficial effects on cell viability.
KYP-2047 reduced the amount of α-synuclein immunoreactivity and soluble α-synuclein protein in the brain in animal models of Parkinson's disease.
KYP-2047 also reduced tongue squamous cell-carcinoma (TSCC) cell viability at 50 and 100 uM, significantly reduced tumor burden and tumor weight, decreasing also angiogenesis markers VEGF and eNOS.
