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KYP-2047

Chemical Structure : KYP-2047

CAS No.: 796874-99-2

KYP-2047 (KYP2047)

Catalog No.: PC-38478Not For Human Use, Lab Use Only.

KYP-2047 is a high affinity prolyl oligopeptidase (PREP) inhibitor with Ki of 0.023 nM, reduces α-synuclein protein levels and aggregates in cellular and animal models of PD.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

KYP-2047 is a high affinity prolyl oligopeptidase (PREP) inhibitor with Ki of 0.023 nM, reduces α-synuclein protein levels and aggregates in cellular and animal models of PD.
KYP-2047 significantly reduced the number of cells with α-synuclein inclusions while abolishing the colocalization of α-synuclein and PREP.
KYP-2047 significantly reduced the amount of aggregated α-synuclein,and it had beneficial effects on cell viability.
KYP-2047 reduced the amount of α-synuclein immunoreactivity and soluble α-synuclein protein in the brain in animal models of Parkinson's disease.
KYP-2047 also reduced tongue squamous cell-carcinoma (TSCC) cell viability at 50 and 100 uM, significantly reduced tumor burden and tumor weight, decreasing also angiogenesis markers VEGF and eNOS.

Physicochemical Properties

M.Wt 339.44
Formula C20H25N3O2
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

(2S)-1-[[(2S)-1-(1-Oxo-4-phenylbutyl)-2-pyrrolidinyl]carbonyl]-2-pyrrolidinecarbonitrile

References

1. Jalkanen AJ, et al. Basic Clin Pharmacol Toxicol. 2011 Dec;109(6):443-51.

2. Jalkanen AJ, et al. Neurosci Lett. 2011 Sep 15;502(2):107-11.

3. Myöhänen TT, et al. Br J Pharmacol. 2012 Jun;166(3):1097-113.

4. Scuderi SA, et al. Oncotarget. 2021 Dec 7;12(25):2459-2473.

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