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Chemical Structure : KLH45
CAS No.: 1632236-44-2
Catalog No.: PC-38539Not For Human Use, Lab Use Only.
KLH45 is a potent, selective and in vivo-active serine hydrolase DDHD2 inhibitor with IC50 of 1.3 nM, shows excellent selectivity against other serine hydrolases with exception of ABHD6.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $98 | In stock | |
| 10 mg | $148 | In stock | |
| 25 mg | $258 | In stock | |
| 50 mg | $428 | In stock | |
| 100 mg | Get quote |
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KLH45 is a potent, selective and in vivo-active serine hydrolase DDHD2 inhibitor with IC50 of 1.3 nM, shows excellent selectivity against other serine hydrolases with exception of ABHD6.
KLH45 inactivated DDHD2 and ABHD6 in Neuro2A cells with low nanomolar in situ potency (<10 nM).
KLH45 (25 nM, 4 h) completely inactivated DDHD2 (>95% inhibition) in Neuro2A cells and showed no cross-reactivity with any of the other 40+ detected serine hydrolases with the exception of ABHD6.
KLH45 (20 mg/kg) promotes elevations triglycerides (TAGs) in the mouse brain.
| M.Wt | 458.485 | |
| Formula | C24H25F3N4O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
N-Cyclohexyl-N-(2-phenylethyl)-4-[4-(trifluoromethoxy)phenyl]-2H-1,2,3-triazole-2-carboxamide |
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1. Jordon M Inloes, et al. Proc Natl Acad Sci U S A. 2014 Oct 14;111(41):14924-9.
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